C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131196 NFATC1 9606 + 18:79395856-79529325 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000253506 NFATC1-001 79395856-79529325 protein_coding
  ENST00000318065 NFATC1-003 79400322-79529323 protein_coding
  ENST00000329101 NFATC1-009 79400336-79529323 protein_coding
  ENST00000397790 NFATC1-002 79395944-79529323 protein_coding
  ENST00000427363 NFATC1-007 79396225-79527577 protein_coding
  ENST00000542384 NFATC1-006 79396225-79527577 protein_coding
  ENST00000545796 NFATC1-201 79400274-79529323 protein_coding
  ENST00000586434 NFATC1-010 79400392-79527577 protein_coding
  ENST00000586695 NFATC1-013 79527119-79528578 processed_transcript
  ENST00000587635 NFATC1-005 79396131-79467676 protein_coding
  ENST00000590172 NFATC1-012 79523924-79529083 processed_transcript
  ENST00000590224 NFATC1-015 79448270-79451068 processed_transcript
  ENST00000590313 NFATC1-008 79400331-79527741 nonsense_mediated_decay
  ENST00000590861 NFATC1-018 79493396-79527665 processed_transcript
  ENST00000591065 NFATC1-016 79448572-79451068 retained_intron
  ENST00000591089 NFATC1-017 79451079-79452131 retained_intron
  ENST00000591814 NFATC1-004 79395930-79470014 protein_coding
  ENST00000592223 NFATC1-011 79400333-79468001 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000253506ENST00000318065ENST00000329101ENST00000397790ENST00000427363ENST00000545796ENST00000586434ENST00000586695ENST00000587635ENST00000590172ENST00000590313ENST00000591065ENST00000591089ENST00000591814ENST00000592223
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000253506 N/A N/A N/A 0.511±0.00 N/A N/A N/A N/A N/A N/A 3.900±0.00 0.914±0.00 0.835±0.00 N/A
ENST00000318065 2.699±0.00 2.551±0.00 0.057±0.00 N/A 3.401±0.00 N/A 0.601±0.50 0.757±0.00 N/A N/A 3.879±0.00 2.077±0.50 1.673±0.00 3.683±0.00
ENST00000329101 N/A N/A N/A 0.292±0.00 N/A 0.576±0.00 1.339±0.00 0.233±0.00 N/A N/A 10.451±0.00 2.387±0.00 1.351±0.23 N/A
ENST00000397790 N/A N/A N/A N/A N/A 0.709±0.00 1.316±0.00 N/A N/A 0.907±0.55 7.588±0.00 N/A N/A 4.658±0.00
ENST00000427363 N/A N/A 0.140±0.00 N/A N/A N/A N/A 0.600±0.00 N/A N/A 1.382±0.00 N/A N/A N/A
ENST00000545796 1.165±0.00 4.578±0.00 N/A 0.574±0.00 2.454±0.00 1.204±0.00 N/A 0.737±0.00 N/A 2.624±0.00 4.116±2.65 N/A 1.484±0.00 2.998±1.36
ENST00000586434 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.463±0.00 N/A N/A
ENST00000586695 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.334±0.00 N/A N/A
ENST00000587635 N/A N/A N/A N/A 0.405±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000590172 N/A N/A 0.214±0.00 0.116±0.00 N/A N/A 0.109±0.00 N/A 0.556±0.00 N/A N/A 1.146±0.85 2.808±0.00 12.729±0.00
ENST00000590313 N/A N/A N/A N/A N/A 0.314±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000591065 N/A N/A 1.731±0.00 N/A N/A N/A N/A 1.222±0.00 N/A N/A N/A N/A N/A N/A
ENST00000591089 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.842±0.00 N/A N/A
ENST00000591814 N/A N/A 0.067±0.00 0.010±0.00 N/A 0.114±0.00 N/A N/A 0.363±0.00 N/A N/A 1.008±0.00 N/A N/A
ENST00000592223 2.292±0.00 4.084±0.00 N/A N/A 2.103±1.97 3.355±0.00 1.815±0.00 0.852±0.00 0.416±0.00 8.983±0.00 N/A 3.047±0.00 1.620±0.30 4.480±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KF CIL_0008KF_0001 VISTA 18:78942193-79542977
CIL_0008IX CIL_0008IX_0001 VISTA 18:78950009-79550795
CIL_0008HP CIL_0008HP_0001 VISTA 18:78983189-79584144
CIL_000016 CIL_000016_0002 CGP 18:79069285-79529325

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IEA G1/S transition of mitotic cell cycle
GO:0000790 IDA nuclear chromatin
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 ISS RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085 ISS RNA polymerase II transcription factor binding
GO:0001205 ISS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001837 IEA epithelial to mesenchymal transition
GO:0003677 IEA DNA binding
GO:0003700 TAS:IEA sequence-specific DNA binding transcription factor activity
GO:0003705 ISS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005528 TAS FK506 binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006816 IEA calcium ion transport
GO:0007507 IEA heart development
GO:0010628 IEA positive regulation of gene expression
GO:0030316 IEA osteoclast differentiation
GO:0035556 IDA intracellular signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045087 TAS innate immune response
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0048273 ISS mitogen-activated protein kinase p38 binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036168 nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 protein_coding Danio_rerio
ENSMUSG00000033016 Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 protein_coding Mus_musculus

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