C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000131467 PSME3 9606 + 17:42824385-42843758 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293362 PSME3-002 42833471-42843757 protein_coding
  ENST00000441946 PSME3-004 42833418-42843216 protein_coding
  ENST00000541124 PSME3-201 42833142-42843758 protein_coding
  ENST00000543428 PSME3-005 42833445-42841695 nonsense_mediated_decay
  ENST00000545225 PSME3-006 42824426-42843239 protein_coding
  ENST00000585805 PSME3-003 42833411-42838798 protein_coding
  ENST00000586114 PSME3-015 42833399-42838985 protein_coding
  ENST00000586312 PSME3-008 42833549-42838976 nonsense_mediated_decay
  ENST00000589469 PSME3-013 42833437-42839303 protein_coding
  ENST00000590720 PSME3-001 42833399-42841578 protein_coding
  ENST00000591152 PSME3-009 42833419-42839009 protein_coding
  ENST00000591722 PSME3-011 42833445-42837755 retained_intron
  ENST00000592169 PSME3-012 42833496-42841671 protein_coding
  ENST00000592458 PSME3-007 42824385-42833026 processed_transcript
  ENST00000592578 PSME3-010 42833418-42834804 processed_transcript
  ENST00000593111 PSME3-014 42834542-42839124 retained_intron
  ENST00000622892 PSME3-202 42833142-42843758 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000293362ENST00000441946ENST00000541124ENST00000590720ENST00000622892
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000293362 8.287±0.00 12.172±0.00 N/A N/A 10.666±0.00 8.718±0.00 4.939±0.00 11.641±0.00 3.810±0.00 6.448±0.00 N/A 14.210±0.00 11.746±0.56 16.466±0.00
ENST00000441946 19.358±0.00 19.330±0.00 2.242±0.00 13.542±9.07 16.303±0.00 8.418±1.23 9.120±0.00 13.731±11.34 8.761±4.76 8.000±0.00 7.417±4.41 38.061±26.11 13.954±1.65 22.133±3.13
ENST00000541124 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.585±0.00 N/A N/A
ENST00000590720 N/A N/A N/A N/A 14.618±0.00 N/A 3.929±0.00 4.502±0.00 7.743±0.00 9.374±0.00 N/A 30.383±0.00 N/A N/A
ENST00000622892 N/A N/A 3.247±0.00 4.735±0.00 N/A N/A 1.629±0.00 N/A N/A 3.722±0.00 N/A 9.525±0.00 11.189±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005S8 CIL_0005S8_0001 CGP 17:42798792-42833350
CIL_0005S9 CIL_0005S9_0001 CGP 17:42810134-42843758
CIL_0004MA CIL_0004MA_0001 CGP 17:42824385-42850707

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0000502 TAS proteasome complex
GO:0002039 IDA p53 binding
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008537 IEA proteasome activator complex
GO:0010467 TAS gene expression
GO:0010950 IDA positive regulation of endopeptidase activity
GO:0016020 IDA membrane
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051436 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0061133 IDA endopeptidase activator activity
GO:0061136 IDA regulation of proteasomal protein catabolic process
GO:0097371 IDA MDM2/MDM4 family protein binding
GO:2001237 IDA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012234 psme3 proteasome activator subunit 3 protein_coding Danio_rerio
ENSMUSG00000078652 Psme3 proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) protein_coding Mus_musculus

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