C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: klotho
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000133116 KL 9606 + 13:33016433-33066145 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380099 KL-001 33016433-33066145 protein_coding
  ENST00000487852 KL-002 33016433-33064303 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380099ENST00000487852
Transcript ID Adipose Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380099 1.154±0.00 12.072±0.00 0.545±0.07 1.203±0.00 0.828±0.32 0.194±0.06 9.787±9.76 0.055±0.00 3.615±0.26 0.344±0.00 0.149±0.04 8.400±1.47 0.637±0.33
ENST00000487852 N/A N/A N/A 0.408±0.00 N/A 0.159±0.03 N/A N/A N/A 0.232±0.00 N/A N/A 0.192±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000UY CIL_0000UY_0001 CGP 13:32586427-33066145
CIL_0000UX CIL_0000UX_0001 CGP 13:33016433-33350630

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002526 IEA acute inflammatory response
GO:0004553 IEA hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004566 IEA beta-glucuronidase activity
GO:0004871 IEA signal transducer activity
GO:0005104 IEA fibroblast growth factor receptor binding
GO:0005179 IEA hormone activity
GO:0005499 IEA vitamin D binding
GO:0005515 IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005975 IEA carbohydrate metabolic process
GO:0006112 IEA energy reserve metabolic process
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007568 IMP aging
GO:0008286 TAS insulin receptor signaling pathway
GO:0008422 TAS beta-glucosidase activity
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0016021 TAS integral component of membrane
GO:0017134 IPI fibroblast growth factor binding
GO:0030501 IMP positive regulation of bone mineralization
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0055074 IEA calcium ion homeostasis
GO:0070062 IDA extracellular vesicular exosome
GO:0090080 IEA positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079862 kl klotho protein_coding Danio_rerio
ENSMUSG00000058488 Kl klotho protein_coding Mus_musculus

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