C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: klotho
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000058488 Kl 10090 + 5:150952607-150993809 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000078856 Kl-201 150952607-150993809 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000078856
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000078856 0.012±0.00 0.104±0.04 0.440±0.00 0.538±0.54 0.062±0.04 0.087±0.04 0.023±0.01 78.798±13.33 0.068±0.09 0.185±0.07 0.088±0.03 1.638±0.78 0.046±0.05 0.188±0.12

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000UY CIL_0000UY_0002 CGP 5:150673739-150993809
CIL_0000UX CIL_0000UX_0002 CGP 5:150952607-151233836

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002526 IEA acute inflammatory response
GO:0004566 IEA beta-glucuronidase activity
GO:0004871 IEA signal transducer activity
GO:0005104 IPI fibroblast growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005576 ISS extracellular region
GO:0005615 IEA extracellular space
GO:0005886 IEA plasma membrane
GO:0005975 IEA carbohydrate metabolic process
GO:0006112 IMP energy reserve metabolic process
GO:0007568 IMP aging
GO:0008286 IEA insulin receptor signaling pathway
GO:0016021 ISS integral component of membrane
GO:0017134 IPI fibroblast growth factor binding
GO:0030501 IEA positive regulation of bone mineralization
GO:0055074 IGI calcium ion homeostasis
GO:0070062 IEA extracellular vesicular exosome
GO:0090080 IGI positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079862 kl klotho protein_coding Danio_rerio
ENSG00000133116 KL klotho protein_coding Homo_sapiens

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