C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: leucyl-tRNA synthetase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000133706 LARS 9606 - 5:146113038-146182660 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000274562 LARS-201 146113896-146182524 protein_coding
  ENST00000394434 LARS-001 146113038-146182660 protein_coding
  ENST00000503654 LARS-011 146168229-146182520 processed_transcript
  ENST00000504323 LARS-005 146142959-146144731 retained_intron
  ENST00000504611 LARS-014 146129083-146130557 retained_intron
  ENST00000505223 LARS-012 146164398-146182650 processed_transcript
  ENST00000506231 LARS-003 146113911-146132626 retained_intron
  ENST00000506436 LARS-010 146172691-146182475 retained_intron
  ENST00000507095 LARS-006 146143487-146151907 processed_transcript
  ENST00000508667 LARS-004 146143244-146151948 retained_intron
  ENST00000508709 LARS-015 146123979-146130216 retained_intron
  ENST00000510191 LARS-002 146113911-146182623 protein_coding
  ENST00000511505 LARS-013 146157397-146182649 processed_transcript
  ENST00000512412 LARS-008 146133057-146143538 processed_transcript
  ENST00000514104 LARS-007 146142782-146144333 retained_intron
  ENST00000618084 LARS-202 146164315-146182625 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000274562ENST00000394434ENST00000508667ENST00000508709ENST00000510191ENST00000618084
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000274562 7.484±0.00 7.189±0.00 N/A 9.955±0.00 6.627±0.00 10.030±0.00 6.237±0.00 9.379±0.00 4.395±1.20 5.467±0.29 8.281±5.18 10.433±1.39 4.623±0.18 10.526±1.42
ENST00000394434 5.728±0.00 4.060±0.00 1.738±0.00 5.088±0.46 1.559±0.00 3.510±0.00 3.309±1.62 N/A 1.535±0.92 1.918±0.00 17.631±0.00 3.586±2.51 3.291±1.40 6.038±0.00
ENST00000508667 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 10.596±0.00 10.944±0.00 15.887±0.00
ENST00000508709 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 27.097±0.00 15.404±0.00 33.668±0.00
ENST00000510191 10.524±0.00 6.251±0.00 4.505±0.00 8.346±1.14 9.890±0.25 10.137±2.25 7.640±1.43 5.417±0.90 2.326±1.58 6.149±1.25 9.619±5.71 8.775±3.72 3.721±0.49 10.818±0.00
ENST00000618084 N/A N/A N/A N/A 9.750±0.00 16.485±0.00 N/A 7.873±0.00 11.437±0.00 N/A N/A 7.949±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001GF CIL_0001GF_0002 CGP 5:146084386-146182660
CIL_0001J0 CIL_0001J0_0002 CGP 5:146113038-146339251

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 IEA nucleotide binding
GO:0002161 IEA aminoacyl-tRNA editing activity
GO:0004812 IEA aminoacyl-tRNA ligase activity
GO:0004823 IEA:TAS leucine-tRNA ligase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006418 IEA tRNA aminoacylation for protein translation
GO:0006429 IEA leucyl-tRNA aminoacylation
GO:0006450 IEA regulation of translational fidelity
GO:0010467 TAS gene expression

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019280 larsb leucyl-tRNA synthetase b protein_coding Danio_rerio
ENSDARG00000089031 larsa leucyl-tRNA synthetase a protein_coding Danio_rerio
ENSDARG00000090988 larsa leucyl-tRNA synthetase a protein_coding Danio_rerio
ENSMUSG00000024493 Lars leucyl-tRNA synthetase protein_coding Mus_musculus

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