C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134001 EIF2S1 9606 + 14:67359997-67386516 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256383 EIF2S1-003 67359997-67386516 protein_coding
  ENST00000466499 EIF2S1-004 67364008-67384122 protein_coding
  ENST00000554332 EIF2S1-001 67382411-67383668 retained_intron
  ENST00000555876 EIF2S1-002 67364898-67382681 protein_coding
  ENST00000556724 EIF2S1-007 67360353-67374648 retained_intron
  ENST00000557310 EIF2S1-006 67360556-67382587 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256383ENST00000466499ENST00000554332ENST00000557310
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256383 11.985±0.00 11.441±0.00 1.990±0.00 9.428±1.24 7.873±2.21 6.492±2.37 6.039±2.54 6.120±2.31 7.191±2.71 7.206±1.81 7.027±5.18 6.297±1.66 5.838±0.60 14.401±0.32
ENST00000466499 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.677±0.00 N/A N/A N/A
ENST00000554332 N/A N/A N/A N/A N/A 39.443±0.00 N/A N/A 18.431±0.00 N/A 49.929±0.00 30.670±0.00 39.918±0.00 64.467±7.47
ENST00000557310 23.628±0.00 N/A N/A N/A N/A 17.736±0.00 N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00010H CIL_00010H_0001 CGP 14:67241109-67360265
CIL_0001KG CIL_0001KG_0002 CGP 14:67294371-67386516
CIL_00010S CIL_00010S_0001 CGP 14:67359997-67412200

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003676 IEA nucleic acid binding
GO:0003723 IEA RNA binding
GO:0003743 IEA:IDA translation initiation factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005844 TAS polysome
GO:0005850 IEA eukaryotic translation initiation factor 2 complex
GO:0005851 IDA eukaryotic translation initiation factor 2B complex
GO:0006412 TAS translation
GO:0006413 IEA:TAS translational initiation
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0010467 TAS gene expression
GO:0010494 ISS cytoplasmic stress granule
GO:0016020 IDA membrane
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0043022 IDA ribosome binding
GO:0043558 IEA regulation of translational initiation in response to stress
GO:0044267 TAS cellular protein metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0046777 IEA protein autophosphorylation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005827 eif2s1a eukaryotic translation initiation factor 2, subunit 1 alpha a protein_coding Danio_rerio
ENSDARG00000052178 eif2s1b eukaryotic translation initiation factor 2, subunit 1 alpha b protein_coding Danio_rerio
ENSMUSG00000021116 Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha protein_coding Mus_musculus

Loading