C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin 6 signal transducer
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134352 IL6ST 9606 - 5:55935095-55994993 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000336909 IL6ST-201 55935099-55976314 protein_coding
  ENST00000381286 IL6ST-005 55941765-55976278 protein_coding
  ENST00000381287 IL6ST-202 55935125-55976314 protein_coding
  ENST00000381293 IL6ST-003 55941765-55976278 protein_coding
  ENST00000381294 IL6ST-012 55941082-55976278 protein_coding
  ENST00000381298 IL6ST-001 55935095-55994993 protein_coding
  ENST00000396816 IL6ST-203 55964209-55976278 protein_coding
  ENST00000423954 IL6ST-008 55947565-55951506 processed_transcript
  ENST00000502326 IL6ST-011 55941028-55994964 protein_coding
  ENST00000503773 IL6ST-006 55940966-55994792 nonsense_mediated_decay
  ENST00000506241 IL6ST-009 55955980-55960480 retained_intron
  ENST00000522633 IL6ST-007 55947561-55982800 protein_coding
  ENST00000523039 IL6ST-010 55941523-55947594 retained_intron
  ENST00000577363 IL6ST-004 55964209-55994794 processed_transcript
  ENST00000583149 IL6ST-013 55941694-55951637 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000336909ENST00000381298ENST00000502326ENST00000522633
Transcript ID Adrenal Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000336909 4.201±0.00 N/A N/A N/A N/A N/A N/A N/A 2.922±1.27 22.140±0.00 5.564±0.00
ENST00000381298 9.766±0.00 10.027±6.05 25.723±0.00 2.535±0.00 37.514±0.00 12.460±0.00 42.383±0.00 3.996±0.00 21.574±7.82 6.700±3.83 2.109±0.00
ENST00000502326 N/A N/A N/A N/A N/A 23.819±0.00 N/A N/A N/A N/A N/A
ENST00000522633 N/A N/A N/A 15.604±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007FX CIL_0007FX_0002 CGP 5:55935095-56233359

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002675 IC positive regulation of acute inflammatory response
GO:0002821 IC positive regulation of adaptive immune response
GO:0004897 IDA ciliary neurotrophic factor receptor activity
GO:0004915 IGI interleukin-6 receptor activity
GO:0004921 IEA interleukin-11 receptor activity
GO:0004923 IGI leukemia inhibitory factor receptor activity
GO:0004924 IDA oncostatin-M receptor activity
GO:0005127 IPI ciliary neurotrophic factor receptor binding
GO:0005138 IPI interleukin-6 receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0005896 IDA interleukin-6 receptor complex
GO:0005900 IDA oncostatin-M receptor complex
GO:0005977 IEA glycogen metabolic process
GO:0007165 IEA signal transduction
GO:0008284 IDA positive regulation of cell proliferation
GO:0008593 IEA regulation of Notch signaling pathway
GO:0009897 IEA external side of plasma membrane
GO:0010575 TAS positive regulation vascular endothelial growth factor production
GO:0010613 TAS positive regulation of cardiac muscle hypertrophy
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019838 IPI growth factor binding
GO:0019970 IEA interleukin-11 binding
GO:0019981 IPI interleukin-6 binding
GO:0030425 IEA dendrite
GO:0034097 IDA response to cytokine
GO:0038154 IEA interleukin-11-mediated signaling pathway
GO:0038165 IMP oncostatin-M-mediated signaling pathway
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042511 IMP positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IMP positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042803 TAS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043066 TAS negative regulation of apoptotic process
GO:0044297 IEA cell body
GO:0045509 IC interleukin-27 receptor activity
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0048711 IEA positive regulation of astrocyte differentiation
GO:0048861 IGI leukemia inhibitory factor signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070102 IMP interleukin-6-mediated signaling pathway
GO:0070104 IDA negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 IMP interleukin-27-mediated signaling pathway
GO:0070110 IDA ciliary neurotrophic factor receptor complex
GO:0070120 IDA ciliary neurotrophic factor-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030498 il6st interleukin 6 signal transducer protein_coding Danio_rerio
ENSMUSG00000021756 Il6st interleukin 6 signal transducer protein_coding Mus_musculus

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