Institute of Cardiovascular Regeneration Webtool Repository

Gene Info
Description:	interleukin 6 signal transducer
Gene Accession	Gene Name	Tax ID	Strand	Position	Gene Biotype
ENSMUSG00000021756	Il6st	10090	+	13:112464070-112510086	protein_coding
	Transcript Accession	Transcript Name	Position	Transcript Biotype
	ENSMUST00000070731	Il6st-201	112475008-112506860	protein_coding
	ENSMUST00000183513	Il6st-006	112475046-112503759	protein_coding
	ENSMUST00000183663	Il6st-001	112464070-112510086	protein_coding
	ENSMUST00000183829	Il6st-005	112475046-112503759	protein_coding
	ENSMUST00000183868	Il6st-009	112467593-112480057	protein_coding
	ENSMUST00000183886	Il6st-002	112464112-112483616	protein_coding
	ENSMUST00000184276	Il6st-004	112464241-112504545	nonsense_mediated_decay
	ENSMUST00000184311	Il6st-007	112464081-112504491	protein_coding
	ENSMUST00000184445	Il6st-003	112472599-112501141	protein_coding
	ENSMUST00000184949	Il6st-008	112475046-112504445	protein_coding

Gene Info

Description:

interleukin 6 signal transducer

Gene Accession

Gene Name

Tax ID

Strand

Position

Gene Biotype

ENSMUSG00000021756

Il6st

10090

13:112464070-112510086

protein_coding

Transcript Accession

Transcript Name

Position

Transcript Biotype

ENSMUST00000070731

Il6st-201

112475008-112506860

protein_coding

ENSMUST00000183513

Il6st-006

112475046-112503759

protein_coding

ENSMUST00000183663

Il6st-001

112464070-112510086

protein_coding

ENSMUST00000183829

Il6st-005

112475046-112503759

protein_coding

ENSMUST00000183868

Il6st-009

112467593-112480057

protein_coding

ENSMUST00000183886

Il6st-002

112464112-112483616

protein_coding

ENSMUST00000184276

Il6st-004

112464241-112504545

nonsense_mediated_decay

ENSMUST00000184311

Il6st-007

112464081-112504491

protein_coding

ENSMUST00000184445

Il6st-003

112472599-112501141

protein_coding

ENSMUST00000184949

Il6st-008

112475046-112504445

protein_coding

Transcript ID	Adipose	Adrenal	Bladder	Brain	Breast	Colon	Heart	Kidney	Liver	Lung	Muscle	Ovary	Placenta	Testis
ENSMUST00000070731	30.557±9.67	27.566±3.93	53.032±11.82	2.584±0.58	23.225±2.32	11.985±1.50	17.460±0.51	8.460±1.29	4.174±2.23	30.976±2.38	22.233±1.26	22.440±2.48	14.029±6.76	1.495±0.35
ENSMUST00000183663	16.477±7.22	4.166±0.00	14.208±1.69	3.003±0.63	6.324±3.31	3.361±1.07	3.495±0.48	10.572±1.06	3.907±2.67	11.462±0.43	2.906±0.21	8.783±3.67	7.141±3.96	0.895±0.13
ENSMUST00000184276	N/A	11.643±0.00	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	10.300±0.44	6.939±0.00	N/A
ENSMUST00000184311	N/A	N/A	N/A	3.855±0.00	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	1.030±0.00
ENSMUST00000184949	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A	12.612±0.65	N/A	N/A

Conserved Regions
Gene is not located within a conserved region.

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO ID	Evidence Type	GO Description
GO:0004897	IEA	ciliary neurotrophic factor receptor activity
GO:0004915	IEA	interleukin-6 receptor activity
GO:0004921	IDA	interleukin-11 receptor activity
GO:0004923	IEA	leukemia inhibitory factor receptor activity
GO:0004924	IEA	oncostatin-M receptor activity
GO:0005127	IEA	ciliary neurotrophic factor receptor binding
GO:0005138	IEA	interleukin-6 receptor binding
GO:0005515	IPI	protein binding
GO:0005615	IEA	extracellular space
GO:0005896	IEA	interleukin-6 receptor complex
GO:0005900	IEA	oncostatin-M receptor complex
GO:0005977	IMP	glycogen metabolic process
GO:0007165	IDA	signal transduction
GO:0008284	IGI	positive regulation of cell proliferation
GO:0008593	IDA	regulation of Notch signaling pathway
GO:0009897	IDA	external side of plasma membrane
GO:0016020	IEA	membrane
GO:0019221	IDA	cytokine-mediated signaling pathway
GO:0019838	IEA	growth factor binding
GO:0019970	IDA	interleukin-11 binding
GO:0019981	IEA	interleukin-6 binding
GO:0030425	IDA	dendrite
GO:0034097	IEA	response to cytokine
GO:0038154	IDA	interleukin-11-mediated signaling pathway
GO:0038165	IEA	oncostatin-M-mediated signaling pathway
GO:0042102	IEA	positive regulation of T cell proliferation
GO:0042511	IEA	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	IEA	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043025	IDA	neuronal cell body
GO:0044297	IDA	cell body
GO:0045669	IEA	positive regulation of osteoblast differentiation
GO:0048711	IMP	positive regulation of astrocyte differentiation
GO:0048861	IEA	leukemia inhibitory factor signaling pathway
GO:0070062	IEA	extracellular vesicular exosome
GO:0070102	IEA	interleukin-6-mediated signaling pathway
GO:0070104	IEA	negative regulation of interleukin-6-mediated signaling pathway
GO:0070106	IEA	interleukin-27-mediated signaling pathway
GO:0070110	IEA	ciliary neurotrophic factor receptor complex
GO:0070120	IEA	ciliary neurotrophic factor-mediated signaling pathway

Gene Ontology

GO ID

Evidence Type

GO Description

GO:0004897

IEA

ciliary neurotrophic factor receptor activity

GO:0004915

IEA

interleukin-6 receptor activity

GO:0004921

IDA

interleukin-11 receptor activity

GO:0004923

IEA

leukemia inhibitory factor receptor activity

GO:0004924

IEA

oncostatin-M receptor activity

GO:0005127

IEA

ciliary neurotrophic factor receptor binding

GO:0005138

IEA

interleukin-6 receptor binding

GO:0005515

IPI

protein binding

GO:0005615

IEA

extracellular space

GO:0005896

IEA

interleukin-6 receptor complex

GO:0005900

IEA

oncostatin-M receptor complex

GO:0005977

IMP

glycogen metabolic process

GO:0007165

IDA

signal transduction

GO:0008284

IGI

positive regulation of cell proliferation

GO:0008593

IDA

regulation of Notch signaling pathway

GO:0009897

IDA

external side of plasma membrane

GO:0016020

IEA

membrane

GO:0019221

IDA

cytokine-mediated signaling pathway

GO:0019838

IEA

growth factor binding

GO:0019970

IDA

interleukin-11 binding

GO:0019981

IEA

interleukin-6 binding

GO:0030425

IDA

dendrite

GO:0034097

IEA

response to cytokine

GO:0038154

IDA

interleukin-11-mediated signaling pathway

GO:0038165

IEA

oncostatin-M-mediated signaling pathway

GO:0042102

IEA

positive regulation of T cell proliferation

GO:0042511

IEA

positive regulation of tyrosine phosphorylation of Stat1 protein

GO:0042517

IEA

positive regulation of tyrosine phosphorylation of Stat3 protein

GO:0043025

IDA

neuronal cell body

GO:0044297

IDA

cell body

GO:0045669

IEA

positive regulation of osteoblast differentiation

GO:0048711

IMP

positive regulation of astrocyte differentiation

GO:0048861

IEA

leukemia inhibitory factor signaling pathway

GO:0070062

IEA

extracellular vesicular exosome

GO:0070102

IEA

interleukin-6-mediated signaling pathway

GO:0070104

IEA

negative regulation of interleukin-6-mediated signaling pathway

GO:0070106

IEA

interleukin-27-mediated signaling pathway

GO:0070110

IEA

ciliary neurotrophic factor receptor complex

GO:0070120

IEA

ciliary neurotrophic factor-mediated signaling pathway

Homologs
ENSEMBL Accession	Gene Name	Description	Biotype	Species
ENSDARG00000030498	il6st	interleukin 6 signal transducer	protein_coding	Danio_rerio
ENSG00000134352	IL6ST	interleukin 6 signal transducer	protein_coding	Homo_sapiens

C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Expression Patterns

Conserved Regions

Gene Ontology

Homologs

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