C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin 6 signal transducer
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000381298 IL6ST-001 ENSG00000134352 9606 - 5:55935095-55994993 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000381298
Transcript ID Adrenal Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000381298 9.766±0.00 10.027±6.05 25.723±0.00 2.535±0.00 37.514±0.00 12.460±0.00 42.383±0.00 3.996±0.00 21.574±7.82 6.700±3.83 2.109±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007FX CIL_0007FX_0002 CGP 5:55935095-56233359

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002675 IC positive regulation of acute inflammatory response
GO:0002821 IC positive regulation of adaptive immune response
GO:0004897 IDA ciliary neurotrophic factor receptor activity
GO:0004915 IGI interleukin-6 receptor activity
GO:0004921 IEA interleukin-11 receptor activity
GO:0004923 IGI leukemia inhibitory factor receptor activity
GO:0004924 IDA oncostatin-M receptor activity
GO:0005127 IPI ciliary neurotrophic factor receptor binding
GO:0005138 IPI interleukin-6 receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005886 TAS plasma membrane
GO:0005896 IDA interleukin-6 receptor complex
GO:0005900 IDA oncostatin-M receptor complex
GO:0005977 IEA glycogen metabolic process
GO:0007165 IEA signal transduction
GO:0008284 IDA positive regulation of cell proliferation
GO:0008593 IEA regulation of Notch signaling pathway
GO:0009897 IEA external side of plasma membrane
GO:0010575 TAS positive regulation vascular endothelial growth factor production
GO:0010613 TAS positive regulation of cardiac muscle hypertrophy
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019838 IPI growth factor binding
GO:0019970 IEA interleukin-11 binding
GO:0019981 IPI interleukin-6 binding
GO:0030425 IEA dendrite
GO:0034097 IDA response to cytokine
GO:0038154 IEA interleukin-11-mediated signaling pathway
GO:0038165 IMP oncostatin-M-mediated signaling pathway
GO:0042102 IMP positive regulation of T cell proliferation
GO:0042511 IMP positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517 IMP positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042803 TAS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043066 TAS negative regulation of apoptotic process
GO:0044297 IEA cell body
GO:0045509 IC interleukin-27 receptor activity
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0048711 IEA positive regulation of astrocyte differentiation
GO:0048861 IGI leukemia inhibitory factor signaling pathway
GO:0070062 IDA extracellular vesicular exosome
GO:0070102 IMP interleukin-6-mediated signaling pathway
GO:0070104 IDA negative regulation of interleukin-6-mediated signaling pathway
GO:0070106 IMP interleukin-27-mediated signaling pathway
GO:0070110 IDA ciliary neurotrophic factor receptor complex
GO:0070120 IDA ciliary neurotrophic factor-mediated signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000070731 Il6st-201 protein_coding Mus_musculus 0 1962
ENSMUST00000183663 Il6st-001 protein_coding Mus_musculus 0 1962
ENSMUST00000184311 Il6st-007 protein_coding Mus_musculus 0 1881
ENSMUST00000184276 Il6st-004 nonsense_mediated_decay Mus_musculus 0 1367
ENSMUST00000184949 Il6st-008 protein_coding Mus_musculus 0 1116
ENSMUST00000184445 Il6st-003 protein_coding Mus_musculus 0 516
ENSMUST00000183513 Il6st-006 protein_coding Mus_musculus 0 204
ENSMUST00000183829 Il6st-005 protein_coding Mus_musculus 0 204

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