C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cell division cycle 73
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134371 CDC73 9606 + 1:193122017-193253901 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000367435 CDC73-001 193122017-193253901 protein_coding
  ENST00000477868 CDC73-003 193233026-193251168 processed_transcript
  ENST00000482484 CDC73-002 193122470-193138173 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000367435ENST00000477868
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000367435 4.061±0.00 2.798±0.00 3.374±0.00 3.577±0.04 4.205±1.17 4.120±1.61 4.367±1.71 3.475±0.84 5.620±4.64 5.494±1.10 1.180±0.02 3.842±0.39 2.675±0.69 3.518±1.37
ENST00000477868 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.830±0.00 4.402±0.00 6.948±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005IF CIL_0005IF_0001 CGP 1:193122017-193253901

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000993 IDA RNA polymerase II core binding
GO:0001711 ISS endodermal cell fate commitment
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006351 IEA transcription, DNA-templated
GO:0006378 IMP mRNA polyadenylation
GO:0007049 IEA cell cycle
GO:0008285 IDA negative regulation of cell proliferation
GO:0010390 IDA histone monoubiquitination
GO:0016055 IEA Wnt signaling pathway
GO:0016593 IDA Cdc73/Paf1 complex
GO:0019827 ISS stem cell maintenance
GO:0030177 IDA positive regulation of Wnt signaling pathway
GO:0031442 IMP positive regulation of mRNA 3'-end processing
GO:0031648 IMP protein destabilization
GO:0032968 IDA positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 IDA histone H2B ubiquitination
GO:0045638 IDA negative regulation of myeloid cell differentiation
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048147 IMP negative regulation of fibroblast proliferation
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0071222 ISS cellular response to lipopolysaccharide
GO:2000134 IDA negative regulation of G1/S transition of mitotic cell cycle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020201 cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) protein_coding Danio_rerio
ENSMUSG00000026361 Cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component protein_coding Mus_musculus

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