C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activin A receptor, type IB
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135503 ACVR1B 9606 + 12:51951667-51997078 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000257963 ACVR1B-002 51951667-51997078 protein_coding
  ENST00000415850 ACVR1B-003 51951744-51987346 protein_coding
  ENST00000426655 ACVR1B-005 51951702-51992341 protein_coding
  ENST00000536420 ACVR1B-006 51951706-51976364 protein_coding
  ENST00000541224 ACVR1B-004 51951701-51994217 protein_coding
  ENST00000542485 ACVR1B-001 51953380-51994925 protein_coding
  ENST00000563121 ACVR1B-008 51984035-51991992 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000257963ENST00000415850ENST00000426655ENST00000536420ENST00000541224ENST00000542485
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000257963 7.427±0.00 4.697±0.00 10.910±7.02 6.605±0.00 4.234±2.04 2.067±0.00 13.254±12.56 2.778±1.78 3.425±2.78 5.719±0.00 8.641±1.88 4.657±0.57 11.525±3.01
ENST00000415850 N/A N/A N/A N/A N/A N/A 1.053±0.00 1.187±0.00 1.309±0.00 N/A 1.817±0.00 N/A N/A
ENST00000426655 N/A N/A N/A N/A N/A N/A 1.568±0.00 N/A N/A 2.120±0.00 N/A N/A N/A
ENST00000536420 N/A N/A N/A N/A N/A 0.647±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000541224 N/A N/A N/A N/A N/A N/A 1.348±0.00 N/A N/A N/A 2.511±0.00 N/A N/A
ENST00000542485 N/A N/A N/A 1.651±0.00 N/A 0.110±0.00 N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006JY CIL_0006JY_0001 CGP 12:51906908-51997078
CIL_0006JZ CIL_0006JZ_0001 CGP 12:51951667-52015889

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0001701 IEA in utero embryonic development
GO:0001942 IEA hair follicle development
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004675 NAS:IEA transmembrane receptor protein serine/threonine kinase activity
GO:0004702 IEA receptor signaling protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005024 IEA transforming growth factor beta-activated receptor activity
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 IDA signal transduction
GO:0007178 TAS transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007417 IEA central nervous system development
GO:0009966 IEA regulation of signal transduction
GO:0009986 IDA cell surface
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010862 IEA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016020 IEA membrane
GO:0016361 TAS activin receptor activity, type I
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017002 IDA activin-activated receptor activity
GO:0018107 IDA peptidyl-threonine phosphorylation
GO:0019838 IPI growth factor binding
GO:0030308 IDA negative regulation of cell growth
GO:0031625 NAS ubiquitin protein ligase binding
GO:0032924 IMP activin receptor signaling pathway
GO:0032927 IDA positive regulation of activin receptor signaling pathway
GO:0034711 IPI inhibin binding
GO:0038092 IGI nodal signaling pathway
GO:0045648 IDA positive regulation of erythrocyte differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IDA SMAD binding
GO:0046545 IEA development of primary female sexual characteristics
GO:0046777 IDA protein autophosphorylation
GO:0046872 IEA metal ion binding
GO:0048185 IDA activin binding
GO:0070062 IDA extracellular vesicular exosome
GO:0097191 IMP extrinsic apoptotic signaling pathway
GO:1901165 IDA positive regulation of trophoblast cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018968 acvr1b activin A receptor, type IB protein_coding Danio_rerio
ENSDARG00000052142 ACVR1B (2 of 2) activin A receptor, type IB protein_coding Danio_rerio
ENSMUSG00000000532 Acvr1b activin A receptor, type 1B protein_coding Mus_musculus

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