C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000447280 SERPINE2-005 ENSG00000135919 9606 - 2:223975682-224038804 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderColonLiverENST00000447280
Transcript ID Bladder Colon Liver
ENST00000447280 0.879±0.00 0.730±0.00 1.057±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006XP CIL_0006XP_0001 CGP 2:223957404-224039319
CIL_0006XO CIL_0006XO_0001 CGP 2:223975112-224402085

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004867 IDA serine-type endopeptidase inhibitor activity
GO:0005102 IPI receptor binding
GO:0005515 IPI protein binding
GO:0005539 IDA glycosaminoglycan binding
GO:0005576 IDA extracellular region
GO:0005615 IEA:IBA extracellular space
GO:0005829 IDA cytosol
GO:0007596 IEA blood coagulation
GO:0008201 IDA heparin binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009611 IEA response to wounding
GO:0010466 IEA negative regulation of peptidase activity
GO:0010544 IEA negative regulation of platelet activation
GO:0010757 IMP negative regulation of plasminogen activation
GO:0010766 IEA negative regulation of sodium ion transport
GO:0010951 IBA negative regulation of endopeptidase activity
GO:0010955 IC negative regulation of protein processing
GO:0014067 IEA negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 IEA cerebellar granular layer morphogenesis
GO:0030195 IDA negative regulation of blood coagulation
GO:0030308 IEA negative regulation of cell growth
GO:0030334 NAS regulation of cell migration
GO:0031012 IDA extracellular matrix
GO:0031091 IDA platelet alpha granule
GO:0031232 IDA extrinsic component of external side of plasma membrane
GO:0031594 ISS neuromuscular junction
GO:0031982 IDA vesicle
GO:0032940 IEA secretion by cell
GO:0033363 IEA secretory granule organization
GO:0042177 IEA negative regulation of protein catabolic process
GO:0042628 IEA mating plug formation
GO:0045861 IDA negative regulation of proteolysis
GO:0045879 IEA negative regulation of smoothened signaling pathway
GO:0048505 IEA regulation of timing of cell differentiation
GO:0048711 IDA positive regulation of astrocyte differentiation
GO:0050974 IEA detection of mechanical stimulus involved in sensory perception
GO:0051966 IEA regulation of synaptic transmission, glutamatergic
GO:0060291 IEA long-term synaptic potentiation
GO:0060384 IEA innervation
GO:0061108 IEA seminal vesicle epithelium development
GO:0090331 ISS negative regulation of platelet aggregation

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000027467 Serpine2-001 protein_coding Mus_musculus 0 1288
ENSMUST00000189793 Serpine2-004 protein_coding Mus_musculus 0 745

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