C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136044 APPL2 9606 - 12:105173296-105236238 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000258530 APPL2-001 105173296-105236238 protein_coding
  ENST00000539978 APPL2-002 105173935-105233450 protein_coding
  ENST00000546731 APPL2-016 105174105-105176374 protein_coding
  ENST00000546768 APPL2-009 105206850-105217683 retained_intron
  ENST00000547439 APPL2-005 105173297-105236203 nonsense_mediated_decay
  ENST00000547790 APPL2-015 105174017-105177455 retained_intron
  ENST00000547809 APPL2-003 105177110-105233154 retained_intron
  ENST00000548425 APPL2-014 105176803-105188449 retained_intron
  ENST00000549056 APPL2-007 105211289-105229860 protein_coding
  ENST00000549573 APPL2-011 105197764-105208019 processed_transcript
  ENST00000549974 APPL2-008 105199332-105211273 nonsense_mediated_decay
  ENST00000550648 APPL2-010 105203423-105207989 retained_intron
  ENST00000551662 APPL2-004 105174208-105236083 protein_coding
  ENST00000552945 APPL2-012 105188375-105195276 processed_transcript
  ENST00000553097 APPL2-006 105207150-105236093 protein_coding
  ENST00000553109 APPL2-013 105174338-105190040 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000258530ENST00000539978ENST00000546731ENST00000546768ENST00000547439ENST00000547790ENST00000547809ENST00000551662
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000258530 11.665±0.00 N/A N/A 3.450±2.75 3.496±0.22 4.007±1.37 5.793±0.00 10.668±0.00 2.334±0.00 3.070±0.00 2.634±0.00 10.990±4.89 7.053±2.01 10.242±2.06
ENST00000539978 N/A N/A N/A 0.868±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000546731 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 27.168±0.00 9.942±0.00 20.470±0.00
ENST00000546768 N/A N/A N/A N/A N/A N/A N/A N/A 3.012±0.00 N/A 0.823±0.00 N/A N/A N/A
ENST00000547439 N/A 2.332±0.00 N/A 0.437±0.00 N/A N/A N/A N/A 1.740±0.00 2.153±0.00 N/A N/A N/A N/A
ENST00000547790 N/A N/A 1.760±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 29.099±0.00 10.739±0.00 19.652±0.00
ENST00000547809 N/A N/A N/A N/A N/A 3.786±0.00 0.397±0.00 N/A N/A 2.702±0.00 N/A 3.830±0.00 N/A N/A
ENST00000551662 N/A N/A N/A 2.435±1.62 N/A 2.082±0.00 0.558±0.00 N/A 1.456±0.00 1.654±0.00 0.469±0.00 3.057±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004G8 CIL_0004G8_0001 CGP 12:105107324-105236238
CIL_0004G6 CIL_0004G6_0001 CGP 12:105173296-105396097

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IC cytoplasm
GO:0007049 IEA cell cycle
GO:0007165 TAS signal transduction
GO:0008283 IDA cell proliferation
GO:0010008 IDA endosome membrane
GO:0016581 IDA NuRD complex
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000078139 appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 protein_coding Danio_rerio
ENSMUSG00000020263 Appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 protein_coding Mus_musculus

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