C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integral membrane protein 2B
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136156 ITM2B 9606 + 13:48233158-48270357 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000378549 ITM2B-003 48233203-48261388 protein_coding
  ENST00000378565 ITM2B-001 48233158-48270357 protein_coding
  ENST00000463839 ITM2B-002 48261137-48263195 nonsense_mediated_decay
  ENST00000607866 ITM2B-004 48253875-48258941 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000378549ENST00000378565ENST00000607866
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000378549 256.777±0.00 210.489±0.00 52.140±0.00 149.907±122.20 153.185±132.04 125.287±109.03 115.966±104.06 333.788±303.90 69.970±48.69 287.373±246.15 38.165±29.91 199.760±159.39 979.277±398.86 195.466±145.34
ENST00000378565 15.581±0.00 14.639±0.00 8.158±0.00 15.000±6.87 10.532±5.46 8.961±5.42 6.430±4.11 22.443±17.22 5.387±0.68 17.129±8.61 2.124±1.16 16.755±11.47 45.153±12.56 14.010±7.33
ENST00000607866 211.972±0.00 184.460±0.00 83.991±0.00 140.219±82.36 135.812±94.79 112.275±83.83 115.168±96.19 267.804±236.51 70.024±33.80 251.276±203.30 43.942±32.04 181.108±129.73 906.337±436.30 152.028±108.52

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00021H CIL_00021H_0002 CGP 13:48053323-48270357

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001540 IPI beta-amyloid binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0005768 IEA endosome
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0007399 TAS nervous system development
GO:0016020 IDA membrane
GO:0030660 IDA Golgi-associated vesicle membrane
GO:0031301 IDA integral component of organelle membrane
GO:0042985 IDA negative regulation of amyloid precursor protein biosynthetic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0070062 IDA extracellular vesicular exosome
GO:0097192 IEA extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000007098 itm2ba integral membrane protein 2Ba protein_coding Danio_rerio
ENSDARG00000041505 itm2bb integral membrane protein 2Bb protein_coding Danio_rerio
ENSMUSG00000022108 Itm2b integral membrane protein 2B protein_coding Mus_musculus

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