C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136237 RAPGEF5 9606 - 7:22118238-22357144 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000344041 RAPGEF5-201 22118291-22356914 protein_coding
  ENST00000401957 RAPGEF5-001 22118238-22193909 protein_coding
  ENST00000405243 RAPGEF5-002 22192177-22357144 protein_coding
  ENST00000420196 RAPGEF5-009 22167070-22220238 protein_coding
  ENST00000451559 RAPGEF5-007 22157864-22193744 nonsense_mediated_decay
  ENST00000458533 RAPGEF5-008 22154570-22194763 protein_coding
  ENST00000468825 RAPGEF5-010 22139757-22145266 retained_intron
  ENST00000471484 RAPGEF5-004 22308447-22356225 processed_transcript
  ENST00000475788 RAPGEF5-005 22191439-22291241 processed_transcript
  ENST00000488366 RAPGEF5-006 22125232-22136072 processed_transcript
  ENST00000497668 RAPGEF5-003 22356310-22356910 processed_transcript
  ENST00000620335 RAPGEF5-202 22118309-22193735 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000344041ENST00000401957ENST00000405243ENST00000420196ENST00000620335
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000344041 9.383±0.00 2.184±0.00 N/A 6.921±3.25 1.647±0.95 1.824±0.43 0.356±0.00 1.877±0.00 N/A N/A N/A 1.960±1.23 0.805±0.12 1.067±0.14
ENST00000401957 N/A N/A N/A 11.930±6.47 1.999±0.00 2.133±0.00 0.456±0.00 N/A 0.534±0.00 N/A 0.438±0.00 0.758±0.41 N/A N/A
ENST00000405243 N/A N/A N/A N/A 1.998±0.00 N/A N/A N/A 0.983±0.00 N/A 0.237±0.00 N/A N/A N/A
ENST00000420196 N/A N/A 5.482±0.00 N/A 12.688±0.00 9.548±0.00 5.484±0.00 9.589±0.00 7.800±0.00 52.085±0.00 N/A 7.544±0.00 N/A N/A
ENST00000620335 4.143±0.00 N/A N/A 5.393±0.00 N/A N/A 0.537±0.00 2.058±0.00 N/A 2.047±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008OS CIL_0008OS_0001 VISTA 7:21751744-22352939

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005088 TAS Ras guanyl-nucleotide exchange factor activity
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007399 NAS nervous system development
GO:0017034 IDA Rap guanyl-nucleotide exchange factor activity
GO:0030742 IPI GTP-dependent protein binding
GO:0032320 TAS positive regulation of Ras GTPase activity
GO:0032854 IDA positive regulation of Rap GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043547 IEA positive regulation of GTPase activity
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074307 rapgef5b Rap guanine nucleotide exchange factor (GEF) 5b protein_coding Danio_rerio
ENSDARG00000075271 rapgef5a Rap guanine nucleotide exchange factor (GEF) 5a protein_coding Danio_rerio
ENSMUSG00000041992 Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 protein_coding Mus_musculus

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