C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SKI-like proto-oncogene
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136603 SKIL 9606 + 3:170357678-170396835 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000259119 SKIL-011 170357726-170392748 protein_coding
  ENST00000413427 SKIL-002 170359623-170392493 protein_coding
  ENST00000426052 SKIL-003 170357734-170392947 protein_coding
  ENST00000458537 SKIL-001 170359623-170396835 protein_coding
  ENST00000465590 SKIL-006 170357685-170360213 processed_transcript
  ENST00000470571 SKIL-009 170361212-170391187 nonsense_mediated_decay
  ENST00000476188 SKIL-007 170357715-170360700 protein_coding
  ENST00000477216 SKIL-005 170357678-170360073 processed_transcript
  ENST00000490894 SKIL-010 170381276-170385049 retained_intron
  ENST00000490989 SKIL-008 170358509-170360160 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000259119ENST00000413427ENST00000426052ENST00000458537
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000259119 N/A N/A 1.771±0.00 2.808±0.00 20.317±0.00 4.348±0.00 1.098±0.00 N/A 3.945±0.00 8.331±0.00 1.765±0.00 10.764±0.00 N/A N/A
ENST00000413427 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.567±0.00 3.081±0.00 10.173±0.00
ENST00000426052 N/A N/A N/A N/A N/A N/A N/A 2.564±0.00 N/A N/A N/A 3.054±0.00 1.788±0.00 5.444±0.00
ENST00000458537 1.027±0.00 1.122±0.00 N/A 1.153±0.00 2.319±0.00 1.109±0.30 0.243±0.00 1.624±0.00 0.803±0.00 2.304±0.51 N/A 3.039±0.87 0.938±0.56 0.848±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XK CIL_0002XK_0001 CGP 3:170222365-170396835
CIL_0002Z6 CIL_0002Z6_0001 CGP 3:170357678-170860380

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001669 IEA acrosomal vesicle
GO:0001825 IEA blastocyst formation
GO:0002260 IEA lymphocyte homeostasis
GO:0003682 ISS chromatin binding
GO:0003714 IDA transcription corepressor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0006351 TAS transcription, DNA-templated
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0007050 ISS cell cycle arrest
GO:0007179 TAS transforming growth factor beta receptor signaling pathway
GO:0007283 IEA spermatogenesis
GO:0007519 IDA skeletal muscle tissue development
GO:0010467 TAS gene expression
GO:0016605 IDA PML body
GO:0019904 IPI protein domain specific binding
GO:0030512 IDA negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032403 IDA protein complex binding
GO:0034097 IEA response to cytokine
GO:0042981 ISS regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0045596 ISS negative regulation of cell differentiation
GO:0046332 IEA SMAD binding
GO:0046677 IEP response to antibiotic
GO:0050772 IMP positive regulation of axonogenesis
GO:0070207 IDA protein homotrimerization
GO:0070208 IDA protein heterotrimerization
GO:0070306 IEA lens fiber cell differentiation
GO:0070848 IDA response to growth factor
GO:1902043 IEA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902231 IEA positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000022904 skilb SKI-like oncogene b protein_coding Danio_rerio
ENSDARG00000023933 skila SKI-like oncogene a protein_coding Danio_rerio
ENSMUSG00000027660 Skil SKI-like protein_coding Mus_musculus

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