C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136699 SMPD4 9606 - 2:130151392-130182750 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000351288 SMPD4-002 130151408-130181601 protein_coding
  ENST00000409031 SMPD4-001 130151409-130182750 protein_coding
  ENST00000412570 SMPD4-013 130151408-130181593 nonsense_mediated_decay
  ENST00000430682 SMPD4-015 130154277-130172492 protein_coding
  ENST00000431183 SMPD4-201 130151392-130181757 protein_coding
  ENST00000433118 SMPD4-012 130151408-130181599 nonsense_mediated_decay
  ENST00000435455 SMPD4-010 130155096-130172656 nonsense_mediated_decay
  ENST00000439029 SMPD4-019 130157361-130181596 nonsense_mediated_decay
  ENST00000439886 SMPD4-004 130151409-130172843 protein_coding
  ENST00000441135 SMPD4-020 130172834-130181542 protein_coding
  ENST00000449159 SMPD4-009 130153356-130156048 protein_coding
  ENST00000451542 SMPD4-016 130155096-130172455 protein_coding
  ENST00000454468 SMPD4-011 130151405-130181579 nonsense_mediated_decay
  ENST00000455548 SMPD4-018 130156046-130157616 processed_transcript
  ENST00000457039 SMPD4-014 130152746-130157255 protein_coding
  ENST00000461187 SMPD4-008 130154094-130156140 retained_intron
  ENST00000473720 SMPD4-017 130156027-130181595 processed_transcript
  ENST00000482171 SMPD4-005 130151409-130157953 retained_intron
  ENST00000491128 SMPD4-006 130151409-130156263 retained_intron
  ENST00000491319 SMPD4-007 130153110-130154100 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000351288ENST00000409031ENST00000433118ENST00000439886ENST00000454468ENST00000457039ENST00000482171ENST00000491128
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000351288 N/A N/A N/A N/A N/A N/A N/A 2.318±0.00 N/A N/A 5.018±0.00 6.537±4.47 10.745±0.88 5.533±0.00
ENST00000409031 1.814±0.00 4.298±0.00 N/A 1.721±1.11 3.356±0.00 1.296±0.53 3.708±0.00 1.636±0.00 0.735±0.35 1.087±0.68 N/A 7.790±0.00 N/A 6.976±0.04
ENST00000433118 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.631±0.00 N/A N/A
ENST00000439886 2.549±0.00 N/A 0.327±0.00 N/A 0.904±0.00 N/A N/A 1.424±0.00 1.906±0.00 2.352±0.00 N/A 6.912±0.19 N/A N/A
ENST00000454468 N/A N/A 0.287±0.00 N/A N/A N/A N/A N/A N/A N/A 0.511±0.00 3.598±2.86 6.716±0.00 N/A
ENST00000457039 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.302±0.00 N/A N/A N/A
ENST00000482171 N/A 4.258±0.00 0.217±0.00 N/A N/A 0.952±0.00 0.215±0.00 1.246±0.00 N/A N/A N/A N/A N/A N/A
ENST00000491128 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 12.446±0.00 N/A 9.602±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004767 TAS sphingomyelin phosphodiesterase activity
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0006665 TAS sphingolipid metabolic process
GO:0006685 IDA sphingomyelin catabolic process
GO:0006687 TAS glycosphingolipid metabolic process
GO:0008152 IEA metabolic process
GO:0016021 IEA integral component of membrane
GO:0044281 TAS small molecule metabolic process
GO:0046475 IDA glycerophospholipid catabolic process
GO:0046513 IDA ceramide biosynthetic process
GO:0046872 IEA metal ion binding
GO:0050290 IEA sphingomyelin phosphodiesterase D activity
GO:0071356 IDA cellular response to tumor necrosis factor

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020730 smpd4 sphingomyelin phosphodiesterase 4 protein_coding Danio_rerio
ENSMUSG00000005899 Smpd4 sphingomyelin phosphodiesterase 4 protein_coding Mus_musculus

Loading