C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dual oxidase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000137857 DUOX1 9606 + 15:45129933-45165576 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000321429 DUOX1-006 45129933-45165576 protein_coding
  ENST00000389037 DUOX1-001 45129994-45165574 protein_coding
  ENST00000557893 DUOX1-004 45147955-45153239 retained_intron
  ENST00000558322 DUOX1-007 45130018-45133934 protein_coding
  ENST00000558446 DUOX1-009 45150300-45151881 retained_intron
  ENST00000558744 DUOX1-011 45153788-45155851 retained_intron
  ENST00000558991 DUOX1-002 45138646-45141039 retained_intron
  ENST00000559219 DUOX1-008 45147546-45148558 retained_intron
  ENST00000559221 DUOX1-012 45152500-45155535 processed_transcript
  ENST00000559716 DUOX1-010 45151829-45160990 retained_intron
  ENST00000561166 DUOX1-005 45138818-45165573 protein_coding
  ENST00000561220 DUOX1-003 45130038-45164966 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000321429ENST00000389037ENST00000557893ENST00000558991ENST00000559221ENST00000559716ENST00000561166
Transcript ID Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000321429 N/A N/A N/A N/A N/A N/A N/A 3.351±0.00 N/A N/A N/A N/A
ENST00000389037 N/A N/A 1.456±0.00 0.575±0.00 0.374±0.00 N/A 1.128±0.00 6.056±1.13 N/A 3.881±0.80 0.747±0.20 3.715±0.00
ENST00000557893 N/A 0.314±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000558991 N/A N/A N/A N/A N/A N/A N/A N/A 0.154±0.00 N/A N/A N/A
ENST00000559221 N/A N/A N/A N/A N/A N/A N/A N/A 5.011±0.00 N/A N/A N/A
ENST00000559716 N/A N/A N/A N/A N/A N/A N/A N/A 0.919±0.00 N/A N/A N/A
ENST00000561166 1.120±0.00 N/A N/A N/A N/A 0.640±0.00 N/A N/A N/A 2.784±0.39 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004DF CIL_0004DF_0001 CGP 15:45114321-45129938
CIL_0004QK CIL_0004QK_0002 CGP 15:45117367-45165576
CIL_0004DG CIL_0004DG_0001 CGP 15:45129933-45201175

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004601 IEA peroxidase activity
GO:0005509 IEA calcium ion binding
GO:0005515 IEA protein binding
GO:0005886 IEA plasma membrane
GO:0006590 IEA thyroid hormone generation
GO:0006979 IEA response to oxidative stress
GO:0016021 IEA integral component of membrane
GO:0016174 NAS NAD(P)H oxidase activity
GO:0016324 NAS apical plasma membrane
GO:0016491 IEA oxidoreductase activity
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0020037 IEA heme binding
GO:0042335 IMP cuticle development
GO:0042446 IEA hormone biosynthetic process
GO:0042554 NAS superoxide anion generation
GO:0042744 IEA hydrogen peroxide catabolic process
GO:0050661 NAS NADP binding
GO:0050665 NAS hydrogen peroxide biosynthetic process
GO:0051591 ISS response to cAMP
GO:0055114 TAS:IEA oxidation-reduction process
GO:0072593 IEA reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062632 duox dual oxidase protein_coding Danio_rerio
ENSMUSG00000033268 Duox1 dual oxidase 1 protein_coding Mus_musculus

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