C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SIX homeobox 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138083 SIX3 9606 + 2:44941898-44946077 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260653 SIX3-001 44941898-44946077 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainBreastColonKidneyLungMuscleOvaryPlacentaTestisENST00000260653
Transcript ID Adipose Bladder Brain Breast Colon Kidney Lung Muscle Ovary Placenta Testis
ENST00000260653 0.008±0.00 0.154±0.00 0.159±0.11 0.117±0.00 0.034±0.00 0.052±0.00 0.285±0.00 0.033±0.00 0.027±0.01 0.021±0.00 0.165±0.13

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001NM CIL_0001NM_0001 CGP 2:44361950-44946077
CIL_0007KD CIL_0007KD_0001 UCNEbase 2:44450120-45456944
CIL_00083B CIL_00083B_0001 VISTA 2:44503430-45105600
CIL_0009CD CIL_0009CD_0001 VISTA 2:44539613-45143485
CIL_0009CC CIL_0009CC_0001 VISTA 2:44579788-45180514
CIL_0007WX CIL_0007WX_0001 VISTA 2:44600956-45202178
CIL_0001NN CIL_0001NN_0001 CGP 2:44941898-45009430

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 ISS protein import into nucleus, translocation
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001205 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001222 IPI transcription corepressor binding
GO:0001654 IDA eye development
GO:0002070 ISS epithelial cell maturation
GO:0002088 ISS lens development in camera-type eye
GO:0003404 ISS optic vesicle morphogenesis
GO:0003677 IEA DNA binding
GO:0003700 ISS sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 ISS transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006606 IEA protein import into nucleus
GO:0007420 TAS brain development
GO:0007601 TAS visual perception
GO:0009946 ISS proximal/distal axis specification
GO:0014016 ISS neuroblast differentiation
GO:0021536 IEA diencephalon development
GO:0021537 ISS telencephalon development
GO:0021797 IEA forebrain anterior/posterior pattern specification
GO:0021798 IDA forebrain dorsal/ventral pattern formation
GO:0021846 ISS cell proliferation in forebrain
GO:0021978 ISS telencephalon regionalization
GO:0021983 ISS pituitary gland development
GO:0030178 IEA negative regulation of Wnt signaling pathway
GO:0042127 ISS regulation of cell proliferation
GO:0042826 IEA histone deacetylase binding
GO:0043010 IEA camera-type eye development
GO:0043565 IEA sequence-specific DNA binding
GO:0045665 ISS negative regulation of neuron differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048512 IEA circadian behavior
GO:0060235 IEA lens induction in camera-type eye
GO:0061074 ISS regulation of neural retina development
GO:0070306 ISS lens fiber cell differentiation
GO:0097402 ISS neuroblast migration
GO:1901987 ISS regulation of cell cycle phase transition
GO:1902692 ISS regulation of neuroblast proliferation
GO:1902742 ISS apoptotic process involved in development
GO:1990086 ISS lens fiber cell apoptotic process
GO:2000177 ISS regulation of neural precursor cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054879 six3b sine oculis homeobox homolog 3b protein_coding Danio_rerio
ENSDARG00000058008 six3a sine oculis homeobox homolog 3a protein_coding Danio_rerio
ENSMUSG00000038805 Six3 sine oculis-related homeobox 3 protein_coding Mus_musculus

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