C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, alpha V
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138448 ITGAV 9606 + 2:186590065-186680901 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261023 ITGAV-001 186590065-186680901 protein_coding
  ENST00000374907 ITGAV-003 186590080-186680897 protein_coding
  ENST00000430709 ITGAV-008 186668877-186676283 protein_coding
  ENST00000433736 ITGAV-004 186600205-186677441 protein_coding
  ENST00000460641 ITGAV-006 186665126-186668020 retained_intron
  ENST00000474571 ITGAV-011 186668845-186669957 processed_transcript
  ENST00000496477 ITGAV-005 186667648-186675638 retained_intron
  ENST00000496854 ITGAV-007 186668524-186669914 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000261023ENST00000374907ENST00000433736
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000261023 10.748±0.00 6.575±0.00 1.446±0.00 16.452±4.50 11.645±1.89 8.988±2.14 25.175±10.13 12.577±11.33 7.374±4.76 10.263±0.46 4.792±0.00 13.273±5.17 12.129±6.65 4.771±2.49
ENST00000374907 N/A N/A 1.500±0.00 N/A 2.276±0.00 3.387±0.00 N/A 16.555±0.00 0.562±0.00 8.314±0.00 N/A 6.188±0.57 4.269±0.00 3.752±0.39
ENST00000433736 N/A N/A 4.538±0.00 3.689±0.00 4.390±0.00 4.274±0.00 9.060±0.00 0.771±0.00 6.275±0.00 5.552±0.00 2.147±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002DB CIL_0002DB_0001 CGP 2:186486156-186680901
CIL_0000Q6 CIL_0000Q6_0001 CGP 2:186590065-186765965

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEP angiogenesis
GO:0001568 IEA blood vessel development
GO:0001618 IEA virus receptor activity
GO:0001846 ISS opsonin binding
GO:0001968 IDA fibronectin binding
GO:0002020 IDA protease binding
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005080 ISS protein kinase C binding
GO:0005245 IDA voltage-gated calcium channel activity
GO:0005515 IPI protein binding
GO:0005886 IDA plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0007155 IDA cell adhesion
GO:0007160 NAS cell-matrix adhesion
GO:0007229 NAS integrin-mediated signaling pathway
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008284 IDA positive regulation of cell proliferation
GO:0008305 NAS integrin complex
GO:0009615 IEA response to virus
GO:0009897 IEA external side of plasma membrane
GO:0009986 ISS cell surface
GO:0010745 IMP negative regulation of macrophage derived foam cell differentiation
GO:0010888 IMP negative regulation of lipid storage
GO:0016020 ISS membrane
GO:0016049 IMP cell growth
GO:0016477 IMP cell migration
GO:0030198 TAS extracellular matrix organization
GO:0030335 IEA positive regulation of cell migration
GO:0031258 IDA lamellipodium membrane
GO:0031527 IDA filopodium membrane
GO:0031528 IDA microvillus membrane
GO:0031589 IMP cell-substrate adhesion
GO:0031994 IDA insulin-like growth factor I binding
GO:0032369 IMP negative regulation of lipid transport
GO:0032587 IDA ruffle membrane
GO:0033690 IEA positive regulation of osteoblast proliferation
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034446 IDA substrate adhesion-dependent cell spreading
GO:0034683 IDA integrin alphav-beta3 complex
GO:0034684 IDA integrin alphav-beta5 complex
GO:0034686 IDA integrin alphav-beta8 complex
GO:0035867 IDA alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035987 IMP endodermal cell differentiation
GO:0038027 IMP apolipoprotein A-I-mediated signaling pathway
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043277 IEA apoptotic cell clearance
GO:0045335 TAS phagocytic vesicle
GO:0045715 IMP negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785 IDA positive regulation of cell adhesion
GO:0046718 TAS viral entry into host cell
GO:0046872 IEA metal ion binding
GO:0050431 ISS transforming growth factor beta binding
GO:0050748 IMP negative regulation of lipoprotein metabolic process
GO:0050764 IDA regulation of phagocytosis
GO:0050840 IDA extracellular matrix binding
GO:0050900 TAS leukocyte migration
GO:0050919 IMP negative chemotaxis
GO:0052066 NAS entry of symbiont into host cell by promotion of host phagocytosis
GO:0070062 IDA extracellular vesicular exosome
GO:0070371 ISS ERK1 and ERK2 cascade
GO:0070588 IDA calcium ion transmembrane transport
GO:0097192 ISS extrinsic apoptotic signaling pathway in absence of ligand
GO:1990430 IDA extracellular matrix protein binding
GO:2000425 ISS regulation of apoptotic cell clearance
GO:2000536 IDA negative regulation of entry of bacterium into host cell
GO:2001237 IMP negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006314 itgav integrin, alpha V protein_coding Danio_rerio
ENSMUSG00000027087 Itgav integrin alpha V protein_coding Mus_musculus

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