C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin alpha V
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000027087 Itgav 10090 + 2:83724397-83806916 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000028499 Itgav-001 83724397-83806916 protein_coding
  ENSMUST00000111740 Itgav-005 83724555-83806916 protein_coding
  ENSMUST00000125360 Itgav-002 83724397-83756797 retained_intron
  ENSMUST00000125402 Itgav-008 83801849-83803985 protein_coding
  ENSMUST00000131192 Itgav-009 83802921-83806916 protein_coding
  ENSMUST00000141725 Itgav-006 83724452-83747944 protein_coding
  ENSMUST00000148256 Itgav-004 83724527-83725789 processed_transcript
  ENSMUST00000151463 Itgav-003 83724466-83748372 retained_intron
  ENSMUST00000155521 Itgav-007 83724457-83740738 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000028499ENSMUST00000111740ENSMUST00000125360ENSMUST00000141725
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000028499 6.543±3.04 5.017±0.90 12.992±0.09 2.370±0.29 5.011±0.70 4.209±0.40 2.259±0.98 12.630±0.77 2.116±0.55 6.842±0.76 1.264±0.53 11.746±2.59 12.825±5.32 0.618±0.28
ENSMUST00000111740 N/A N/A N/A 2.799±0.00 N/A N/A N/A N/A 0.641±0.25 N/A 0.947±0.47 6.883±0.00 7.990±1.27 0.334±0.02
ENSMUST00000125360 N/A 5.055±0.27 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.556±0.00 N/A N/A
ENSMUST00000141725 N/A 34.160±7.09 N/A N/A 17.715±6.88 12.966±2.66 N/A 15.057±0.00 2.172±0.39 12.631±3.87 N/A 52.985±6.31 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002DB CIL_0002DB_0002 CGP 2:83644435-83806916
CIL_0000Q6 CIL_0000Q6_0002 CGP 2:83724397-83883486

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001568 IMP blood vessel development
GO:0001846 IDA opsonin binding
GO:0001968 IEA fibronectin binding
GO:0002020 IEA protease binding
GO:0005080 IDA protein kinase C binding
GO:0005245 IEA voltage-gated calcium channel activity
GO:0005515 IEA protein binding
GO:0005886 IDA plasma membrane
GO:0005925 IEA focal adhesion
GO:0006954 TAS inflammatory response
GO:0007155 ISS cell adhesion
GO:0007160 TAS cell-matrix adhesion
GO:0007229 IEA integrin-mediated signaling pathway
GO:0008284 ISS positive regulation of cell proliferation
GO:0008305 ISS integrin complex
GO:0009566 NAS fertilization
GO:0009897 IDA external side of plasma membrane
GO:0009986 ISS cell surface
GO:0010745 ISS negative regulation of macrophage derived foam cell differentiation
GO:0010888 ISS negative regulation of lipid storage
GO:0016020 IDA membrane
GO:0016049 IEA cell growth
GO:0016477 IEA cell migration
GO:0030335 IMP positive regulation of cell migration
GO:0031258 IEA lamellipodium membrane
GO:0031527 IEA filopodium membrane
GO:0031528 IEA microvillus membrane
GO:0031589 IEA cell-substrate adhesion
GO:0031994 ISS insulin-like growth factor I binding
GO:0032369 ISS negative regulation of lipid transport
GO:0032490 TAS detection of molecule of bacterial origin
GO:0032587 IEA ruffle membrane
GO:0033690 IMP positive regulation of osteoblast proliferation
GO:0034113 IEA heterotypic cell-cell adhesion
GO:0034446 IEA substrate adhesion-dependent cell spreading
GO:0034683 TAS integrin alphav-beta3 complex
GO:0034684 IEA integrin alphav-beta5 complex
GO:0034686 IEA integrin alphav-beta8 complex
GO:0035262 NAS gonad morphogenesis
GO:0035867 IEA alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035987 IEA endodermal cell differentiation
GO:0038027 IEA apolipoprotein A-I-mediated signaling pathway
GO:0042110 TAS T cell activation
GO:0043277 IMP apoptotic cell clearance
GO:0043542 TAS endothelial cell migration
GO:0045124 TAS regulation of bone resorption
GO:0045715 ISS negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0045785 ISS positive regulation of cell adhesion
GO:0046872 IEA metal ion binding
GO:0046982 TAS protein heterodimerization activity
GO:0048041 NAS focal adhesion assembly
GO:0050431 ISS transforming growth factor beta binding
GO:0050748 ISS negative regulation of lipoprotein metabolic process
GO:0050764 ISS regulation of phagocytosis
GO:0050840 IEA extracellular matrix binding
GO:0050919 IEA negative chemotaxis
GO:0051209 TAS release of sequestered calcium ion into cytosol
GO:0060707 TAS trophoblast giant cell differentiation
GO:0070062 IEA extracellular vesicular exosome
GO:0070371 IDA ERK1 and ERK2 cascade
GO:0070588 IEA calcium ion transmembrane transport
GO:0071731 TAS response to nitric oxide
GO:0097192 IDA extrinsic apoptotic signaling pathway in absence of ligand
GO:1990430 IEA extracellular matrix protein binding
GO:2000425 IDA regulation of apoptotic cell clearance
GO:2000536 ISS negative regulation of entry of bacterium into host cell
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006314 itgav integrin, alpha V protein_coding Danio_rerio
ENSG00000138448 ITGAV integrin, alpha V protein_coding Homo_sapiens

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