C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138622 HCN4 9606 - 15:73319859-73369264 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000261917 HCN4-001 73319859-73369264 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000261917
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000261917 0.014±0.00 0.010±0.00 0.426±0.20 0.019±0.01 0.082±0.00 1.997±1.72 0.234±0.00 0.023±0.02 0.109±0.00 0.031±0.02 0.011±0.00 3.223±0.30

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000HP CIL_0000HP_0002 CGP 15:73319859-73560014

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0002027 IMP regulation of heart rate
GO:0005216 IEA ion channel activity
GO:0005222 IDA intracellular cAMP activated cation channel activity
GO:0005248 IMP voltage-gated sodium channel activity
GO:0005249 IBA voltage-gated potassium channel activity
GO:0005261 TAS cation channel activity
GO:0005515 IEA protein binding
GO:0005886 IDA plasma membrane
GO:0005887 IBA integral component of plasma membrane
GO:0006811 IEA ion transport
GO:0006812 TAS cation transport
GO:0006936 TAS muscle contraction
GO:0007268 TAS synaptic transmission
GO:0008015 NAS blood circulation
GO:0008016 IEA regulation of heart contraction
GO:0016020 IEA membrane
GO:0030552 IEA cAMP binding
GO:0031226 IDA intrinsic component of plasma membrane
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IMP sodium ion transmembrane transport
GO:0042391 IBA regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0043195 IEA terminal bouton
GO:0055085 IEA transmembrane transport
GO:0071320 IDA cellular response to cAMP
GO:0071321 IDA cellular response to cGMP
GO:0071805 IBA potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061685 hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 protein_coding Danio_rerio
ENSDARG00000074419 hcn4l hyperpolarization activated cyclic nucleotide-gated potassium channel 4l protein_coding Danio_rerio
ENSMUSG00000032338 Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 protein_coding Mus_musculus

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