C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000261917 HCN4-001 ENSG00000138622 9606 - 15:73319859-73369264 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000261917
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000261917 0.014±0.00 0.010±0.00 0.426±0.20 0.019±0.01 0.082±0.00 1.997±1.72 0.234±0.00 0.023±0.02 0.109±0.00 0.031±0.02 0.011±0.00 3.223±0.30

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000HP CIL_0000HP_0002 CGP 15:73319859-73560014

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0002027 IMP regulation of heart rate
GO:0005216 IEA ion channel activity
GO:0005222 IDA intracellular cAMP activated cation channel activity
GO:0005248 IMP voltage-gated sodium channel activity
GO:0005249 IBA voltage-gated potassium channel activity
GO:0005261 TAS cation channel activity
GO:0005515 IEA protein binding
GO:0005886 IDA plasma membrane
GO:0005887 IBA integral component of plasma membrane
GO:0006811 IEA ion transport
GO:0006812 TAS cation transport
GO:0006936 TAS muscle contraction
GO:0007268 TAS synaptic transmission
GO:0008015 NAS blood circulation
GO:0008016 IEA regulation of heart contraction
GO:0016020 IEA membrane
GO:0030552 IEA cAMP binding
GO:0031226 IDA intrinsic component of plasma membrane
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IMP sodium ion transmembrane transport
GO:0042391 IBA regulation of membrane potential
GO:0042802 IPI identical protein binding
GO:0043195 IEA terminal bouton
GO:0055085 IEA transmembrane transport
GO:0071320 IDA cellular response to cAMP
GO:0071321 IDA cellular response to cGMP
GO:0071805 IBA potassium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034889 Hcn4-201 protein_coding Mus_musculus 0 4715
ENSMUST00000020581 Hcn2-201 protein_coding Mus_musculus 0 1591
ENSMUST00000099513 Hcn2-001 protein_coding Mus_musculus 0 1591
ENSDART00000093300 hcn4-201 protein_coding Danio_rerio 0 1498
ENSDART00000136140 hcn4-001 protein_coding Danio_rerio 0 1498
ENSDART00000088249 hcn4l-201 protein_coding Danio_rerio 0 1229
ENSDART00000136390 hcn2b-001 protein_coding Danio_rerio 0 1177
ENSMUST00000029686 Hcn3-001 protein_coding Mus_musculus 0 1158
ENSDART00000131044 HCN2 (2 of 2)-201 protein_coding Danio_rerio 0 1149
ENSDART00000148940 hcn4l-001 protein_coding Danio_rerio 0 1101
ENSDART00000151713 hcn3-201 protein_coding Danio_rerio 0 765
ENSDART00000039325 hcn3-001 protein_coding Danio_rerio 0 765
ENSMUST00000132156 Hcn3-003 retained_intron Mus_musculus 0 675
ENSMUST00000127654 Hcn3-004 retained_intron Mus_musculus 0 433

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