C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dual specificity phosphatase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000139318 DUSP6 9606 - 12:89347232-89353271 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000279488 DUSP6-001 89347232-89353271 protein_coding
  ENST00000308385 DUSP6-002 89348369-89352405 protein_coding
  ENST00000547140 DUSP6-004 89349482-89351582 processed_transcript
  ENST00000547291 DUSP6-005 89349072-89351171 protein_coding
  ENST00000548755 DUSP6-003 89351689-89352497 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainColonHeartLungMuscleOvaryTestisENST00000279488ENST00000308385ENST00000547291
Transcript ID Adrenal Bladder Brain Colon Heart Lung Muscle Ovary Testis
ENST00000279488 N/A N/A 0.780±0.00 N/A N/A 1.593±0.00 N/A 1.191±0.00 N/A
ENST00000308385 6.699±0.00 1.446±0.00 1.507±0.00 2.005±0.00 2.306±0.00 N/A N/A 2.577±0.00 2.236±0.00
ENST00000547291 N/A 3.854±0.00 N/A 2.682±0.00 2.643±0.00 N/A 1.256±0.00 2.443±0.20 1.672±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000213 CIL_000213_0002 CGP 12:89347232-89526024

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000188 IDA inactivation of MAPK activity
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004721 IEA phosphoprotein phosphatase activity
GO:0004725 IEA protein tyrosine phosphatase activity
GO:0005515 IEA protein binding
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 IEA cytosol
GO:0006470 IEA protein dephosphorylation
GO:0008138 IEA protein tyrosine/serine/threonine phosphatase activity
GO:0009953 IBA dorsal/ventral pattern formation
GO:0010033 IEA response to organic substance
GO:0010942 IEA positive regulation of cell death
GO:0014070 IEA response to organic cyclic compound
GO:0016311 IEA dephosphorylation
GO:0016791 IEA phosphatase activity
GO:0017017 IDA:IEA MAP kinase tyrosine/serine/threonine phosphatase activity
GO:0030154 IEA cell differentiation
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035335 IDA peptidyl-tyrosine dephosphorylation
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0040036 IBA regulation of fibroblast growth factor receptor signaling pathway
GO:0042493 IEA response to drug
GO:0042663 IBA regulation of endodermal cell fate specification
GO:0043065 IDA positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051403 TAS stress-activated MAPK cascade
GO:0051409 IEP response to nitrosative stress
GO:0060420 IBA regulation of heart growth
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:0070848 IEA response to growth factor

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070914 dusp6 dual specificity phosphatase 6 protein_coding Danio_rerio
ENSMUSG00000019960 Dusp6 dual specificity phosphatase 6 protein_coding Mus_musculus

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