C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fat mass and obesity associated
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140718 FTO 9606 + 16:53703963-54121941 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268349 FTO-008 53934030-54114463 protein_coding
  ENST00000431610 FTO-006 53886917-54112138 protein_coding
  ENST00000460382 FTO-002 53886930-54112987 protein_coding
  ENST00000463855 FTO-005 53911256-54114463 protein_coding
  ENST00000464071 FTO-003 53704182-54112087 nonsense_mediated_decay
  ENST00000471389 FTO-001 53703963-54121941 protein_coding
  ENST00000472835 FTO-007 54063637-54112302 processed_transcript
  ENST00000570395 FTO-009 53704156-53825968 processed_transcript

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000268349ENST00000463855ENST00000464071ENST00000471389
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000268349 10.916±0.00 8.191±0.00 2.551±0.00 19.439±6.21 13.679±0.00 5.623±3.28 3.083±1.32 5.724±3.36 5.173±0.12 6.958±3.70 6.344±5.31 5.343±2.72 7.145±0.36 5.652±3.18
ENST00000463855 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.018±0.00 N/A N/A
ENST00000464071 12.597±0.00 8.627±0.00 6.088±0.00 30.425±1.46 12.123±0.81 6.073±0.49 7.658±0.00 8.735±0.75 7.220±4.49 11.379±1.73 9.242±2.03 10.956±8.32 6.068±1.47 6.240±2.53
ENST00000471389 0.807±0.00 0.595±0.00 1.041±0.00 2.199±0.34 1.204±0.33 0.568±0.00 0.905±0.00 0.727±0.04 0.403±0.18 1.473±0.59 0.720±0.04 1.086±0.54 0.676±0.27 0.625±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ON CIL_0007ON_0002 UCNEbase 16:51906374-55391377
CIL_0007PV CIL_0007PV_0001 VISTA 16:53229142-53830543
CIL_0008IZ CIL_0008IZ_0001 VISTA 16:53244122-53845073
CIL_0007S1 CIL_0007S1_0001 VISTA 16:53392404-53993644
CIL_0007S0 CIL_0007S0_0001 VISTA 16:53426386-54027245
CIL_0007SA CIL_0007SA_0001 VISTA 16:53595301-54195912
CIL_0005OE CIL_0005OE_0001 CGP 16:53597683-54121941
CIL_0007X2 CIL_0007X2_0001 VISTA 16:53614289-54215934
CIL_0007X0 CIL_0007X0_0001 VISTA 16:53652718-54254281
CIL_0007WZ CIL_0007WZ_0001 VISTA 16:53660146-54262031
CIL_0000UO CIL_0000UO_0001 CGP 16:53703963-54286763

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001659 IEA temperature homeostasis
GO:0005634 ISS nucleus
GO:0006307 IDA DNA dealkylation involved in DNA repair
GO:0008198 IDA ferrous iron binding
GO:0010883 IEA regulation of lipid storage
GO:0016607 IDA nuclear speck
GO:0035515 IDA oxidative RNA demethylase activity
GO:0035516 IDA oxidative DNA demethylase activity
GO:0035552 IDA oxidative single-stranded DNA demethylation
GO:0035553 IDA oxidative single-stranded RNA demethylation
GO:0040014 IEA regulation of multicellular organism growth
GO:0042245 IDA RNA repair
GO:0043734 IDA DNA-N1-methyladenine dioxygenase activity
GO:0044065 IEA regulation of respiratory system process
GO:0060612 IEA adipose tissue development
GO:0070350 IEA regulation of white fat cell proliferation
GO:0070989 IDA oxidative demethylation
GO:0080111 IDA DNA demethylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044216 fto fat mass and obesity associated protein_coding Danio_rerio
ENSMUSG00000055932 Fto fat mass and obesity associated protein_coding Mus_musculus

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