C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fat mass and obesity associated
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000055932 Fto 10090 + 8:91313532-91668439 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000069718 Fto-001 91313532-91668439 protein_coding
  ENSMUST00000125471 Fto-002 91313535-91444766 retained_intron
  ENSMUST00000128081 Fto-005 91313558-91526230 retained_intron
  ENSMUST00000136802 Fto-004 91313568-91487791 retained_intron
  ENSMUST00000140276 Fto-003 91467685-91666946 processed_transcript
  ENSMUST00000149913 Fto-006 91390555-91409464 protein_coding
  ENSMUST00000166548 Fto-007 91387736-91409840 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000069718ENSMUST00000140276
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000069718 24.486±2.38 16.514±2.48 27.982±0.38 41.561±19.29 21.056±4.40 12.488±0.62 18.887±1.37 21.556±0.61 9.817±0.83 19.840±1.36 26.728±1.18 26.244±5.39 12.559±5.42 19.767±8.24
ENSMUST00000140276 N/A N/A N/A 74.177±0.00 N/A N/A N/A N/A N/A N/A N/A 46.370±0.00 19.704±0.38 25.350±13.65

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007ON CIL_0007ON_0003 UCNEbase 8:88447800-92743752
CIL_0007PV CIL_0007PV_0002 VISTA 8:90870647-91472060
CIL_0008IZ CIL_0008IZ_0002 VISTA 8:90885299-91486231
CIL_0007S1 CIL_0007S1_0002 VISTA 8:91005057-91606285
CIL_0007S0 CIL_0007S0_0002 VISTA 8:91042027-91642872
CIL_0007SA CIL_0007SA_0002 VISTA 8:91191445-91792009
CIL_0007X2 CIL_0007X2_0002 VISTA 8:91208767-91810326
CIL_0005OE CIL_0005OE_0002 CGP 8:91217030-91668439
CIL_0007X0 CIL_0007X0_0002 VISTA 8:91238298-91839821
CIL_0007WZ CIL_0007WZ_0002 VISTA 8:91245726-91847572
CIL_0000UO CIL_0000UO_0002 CGP 8:91313532-91801916

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001659 IMP temperature homeostasis
GO:0005634 IDA nucleus
GO:0006307 ISS DNA dealkylation involved in DNA repair
GO:0008198 ISS ferrous iron binding
GO:0010883 IMP regulation of lipid storage
GO:0016607 ISS nuclear speck
GO:0035515 IDA oxidative RNA demethylase activity
GO:0035516 IDA oxidative DNA demethylase activity
GO:0035552 IDA oxidative single-stranded DNA demethylation
GO:0035553 IDA oxidative single-stranded RNA demethylation
GO:0040014 IMP regulation of multicellular organism growth
GO:0042245 IDA RNA repair
GO:0043734 IDA DNA-N1-methyladenine dioxygenase activity
GO:0044065 IMP regulation of respiratory system process
GO:0060612 IMP adipose tissue development
GO:0070350 IMP regulation of white fat cell proliferation
GO:0070989 IDA oxidative demethylation
GO:0080111 IDA DNA demethylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000044216 fto fat mass and obesity associated protein_coding Danio_rerio
ENSG00000140718 FTO fat mass and obesity associated protein_coding Homo_sapiens

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