C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000142082 SIRT3 9606 - 11:215458-236931 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000382743 SIRT3-001 215458-236431 protein_coding
  ENST00000524564 SIRT3-002 216391-236354 protein_coding
  ENST00000525237 SIRT3-010 233209-236326 protein_coding
  ENST00000525319 SIRT3-003 216206-236354 protein_coding
  ENST00000525776 SIRT3-011 233192-233683 protein_coding
  ENST00000526854 SIRT3-016 224167-236330 nonsense_mediated_decay
  ENST00000528469 SIRT3-009 232983-236859 protein_coding
  ENST00000528702 SIRT3-007 225673-236931 processed_transcript
  ENST00000529055 SIRT3-015 224222-236339 nonsense_mediated_decay
  ENST00000529382 SIRT3-008 216611-236834 protein_coding
  ENST00000529937 SIRT3-006 216145-236337 nonsense_mediated_decay
  ENST00000530067 SIRT3-014 230603-236345 nonsense_mediated_decay
  ENST00000531753 SIRT3-012 224090-233928 processed_transcript
  ENST00000532837 SIRT3-005 216179-236343 nonsense_mediated_decay
  ENST00000532956 SIRT3-004 216525-236352 protein_coding
  ENST00000534381 SIRT3-013 225762-230692 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BrainColonHeartKidneyOvaryENST00000382743ENST00000525319
Transcript ID Brain Colon Heart Kidney Ovary
ENST00000382743 11.544±0.00 1.272±0.00 6.230±0.00 8.978±0.00 10.319±1.34
ENST00000525319 N/A N/A 9.862±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006LA CIL_0006LA_0001 CGP 11:207511-236931
CIL_0006QN CIL_0006QN_0001 CGP 11:215458-252984

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI protein binding
GO:0005737 IEA cytoplasm
GO:0005739 IDA mitochondrion
GO:0006476 IDA:IEA protein deacetylation
GO:0007568 IEA aging
GO:0008270 IDA:IEA zinc ion binding
GO:0009060 IMP aerobic respiration
GO:0016020 IEA membrane
GO:0016811 IEA hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0019899 IEA enzyme binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0034983 IMP peptidyl-lysine deacetylation
GO:0051287 IEA NAD binding
GO:0070403 IEA NAD+ binding
GO:0070932 IEA histone H3 deacetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035819 sirt3 sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) protein_coding Danio_rerio
ENSMUSG00000025486 Sirt3 sirtuin 3 protein_coding Mus_musculus

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