C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143207 RFWD2 9606 - 1:175944831-176207493 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308769 RFWD2-010 175945153-176206978 protein_coding
  ENST00000367666 RFWD2-003 175944832-176184664 protein_coding
  ENST00000367667 RFWD2-002 175944831-176206691 nonsense_mediated_decay
  ENST00000367669 RFWD2-001 175944831-176207493 protein_coding
  ENST00000459744 RFWD2-008 176043216-176135082 protein_coding
  ENST00000461830 RFWD2-004 175944831-176081256 retained_intron
  ENST00000474194 RFWD2-006 176135010-176207083 nonsense_mediated_decay
  ENST00000482305 RFWD2-005 175944853-175947326 retained_intron
  ENST00000491600 RFWD2-007 176116646-176206440 nonsense_mediated_decay
  ENST00000498306 RFWD2-009 176085866-176206381 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000308769ENST00000367666ENST00000367667ENST00000367669ENST00000459744ENST00000461830ENST00000474194ENST00000482305ENST00000498306
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000308769 N/A N/A 0.889±0.00 3.201±0.00 3.681±0.00 2.322±0.00 0.921±0.33 N/A 2.552±0.00 3.107±0.62 N/A 10.465±0.00 9.406±0.00 12.064±0.00
ENST00000367666 4.048±0.00 4.974±0.00 N/A 3.696±0.00 3.498±0.90 2.499±1.12 1.037±0.00 6.281±0.00 2.882±0.00 1.701±0.00 1.233±0.00 6.081±1.37 3.769±1.13 10.194±3.52
ENST00000367667 5.496±0.00 4.502±0.00 1.245±0.00 1.911±0.00 5.627±0.00 N/A 1.172±0.00 2.080±0.00 2.038±0.00 3.426±0.00 1.663±0.00 4.979±1.33 3.095±0.00 6.341±0.68
ENST00000367669 N/A 2.046±0.00 N/A N/A 2.671±0.00 2.539±1.59 1.116±0.82 2.519±0.79 1.366±0.21 1.882±0.83 1.004±0.00 3.417±1.31 3.397±0.52 2.860±0.00
ENST00000459744 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.624±0.00 9.186±0.00 N/A 15.672±0.00
ENST00000461830 N/A N/A N/A N/A 1.665±0.00 1.762±0.00 N/A N/A N/A 2.197±0.00 N/A N/A N/A N/A
ENST00000474194 N/A N/A N/A N/A 4.232±0.00 N/A 0.805±0.00 N/A 3.028±0.00 N/A 0.995±0.00 N/A N/A N/A
ENST00000482305 N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.194±0.00 N/A N/A N/A N/A
ENST00000498306 N/A N/A N/A N/A N/A N/A N/A 4.951±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000139 IEA Golgi membrane
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 TAS cytosol
GO:0005925 IDA focal adhesion
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008270 IEA zinc ion binding
GO:0010212 IDA response to ionizing radiation
GO:0016567 IEA protein ubiquitination
GO:0016874 IEA ligase activity
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0046872 IEA metal ion binding
GO:0061630 IMP ubiquitin protein ligase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079329 rfwd2 ring finger and WD repeat domain 2 protein_coding Danio_rerio
ENSMUSG00000040782 Rfwd2 ring finger and WD repeat domain 2 protein_coding Mus_musculus

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