C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DIS3 like 3'-5' exoribonuclease 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000144535 DIS3L2 9606 + 2:231961245-232344350 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000273009 DIS3L2-001 231961245-232344350 protein_coding
  ENST00000325385 DIS3L2-201 231961583-232337197 protein_coding
  ENST00000390005 DIS3L2-002 231961684-232337198 nonsense_mediated_decay
  ENST00000409307 DIS3L2-015 232014928-232336630 protein_coding
  ENST00000409401 DIS3L2-003 231961684-232131890 protein_coding
  ENST00000417808 DIS3L2-007 232335785-232336973 protein_coding
  ENST00000418143 DIS3L2-012 232334660-232336974 protein_coding
  ENST00000424049 DIS3L2-010 232163604-232334454 protein_coding
  ENST00000429283 DIS3L2-006 232328508-232336976 retained_intron
  ENST00000433430 DIS3L2-005 232014928-232336977 nonsense_mediated_decay
  ENST00000434477 DIS3L2-011 232333943-232340999 protein_coding
  ENST00000441279 DIS3L2-008 231961708-232087552 protein_coding
  ENST00000445090 DIS3L2-004 231961692-232336555 nonsense_mediated_decay
  ENST00000464554 DIS3L2-013 232015601-232087844 retained_intron
  ENST00000470087 DIS3L2-009 232015852-232130875 processed_transcript
  ENST00000498319 DIS3L2-014 232249340-232307778 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000273009ENST00000325385ENST00000390005ENST00000409307ENST00000409401ENST00000424049ENST00000433430ENST00000441279ENST00000464554
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000273009 N/A 1.435±0.00 1.112±0.00 N/A 0.906±0.00 1.041±0.27 0.496±0.00 1.347±0.00 N/A 1.770±0.00 N/A 2.478±0.52 N/A N/A
ENST00000325385 1.874±0.00 2.761±0.00 N/A 2.305±1.23 1.915±0.00 1.157±0.00 1.158±0.51 4.091±0.00 1.977±0.00 1.957±0.00 2.322±0.00 2.990±0.23 2.668±0.00 6.129±0.00
ENST00000390005 N/A N/A N/A N/A 1.998±0.00 N/A N/A N/A 1.276±0.00 N/A 0.369±0.00 4.931±0.00 3.368±0.00 9.070±0.00
ENST00000409307 1.767±0.00 2.292±0.00 N/A N/A 1.015±0.00 1.994±0.00 0.595±0.00 1.067±0.00 N/A 2.337±0.77 1.801±0.00 5.154±0.00 2.266±0.30 N/A
ENST00000409401 N/A N/A N/A N/A 2.814±0.00 N/A 0.950±0.00 N/A 1.165±0.00 1.761±0.00 0.692±0.00 1.718±0.00 N/A N/A
ENST00000424049 2.711±0.00 N/A N/A 6.705±0.00 3.673±0.00 N/A 2.223±0.00 N/A N/A N/A 2.826±0.57 N/A 3.788±0.00 8.453±0.00
ENST00000433430 N/A 1.128±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.919±0.00
ENST00000441279 N/A N/A N/A 4.725±0.00 N/A N/A N/A 1.939±0.00 3.665±0.00 N/A 1.901±0.00 3.771±0.00 N/A N/A
ENST00000464554 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.919±0.00 6.912±0.00 25.755±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000899 CIL_000899_0001 VISTA 2:231361987-231963495
CIL_0007WD CIL_0007WD_0001 VISTA 2:231362545-231967398
CIL_0007FN CIL_0007FN_0001 CGP 2:231921820-232344350
CIL_0007FQ CIL_0007FQ_0001 CGP 2:231961245-232382889

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000175 IDA 3'-5'-exoribonuclease activity
GO:0000287 IDA magnesium ion binding
GO:0000291 IMP nuclear-transcribed mRNA catabolic process, exonucleolytic
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0004540 IDA ribonuclease activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005844 TAS polysome
GO:0007067 IMP mitotic nuclear division
GO:0008266 IDA poly(U) RNA binding
GO:0008285 IMP negative regulation of cell proliferation
GO:0010587 ISS miRNA catabolic process
GO:0019827 ISS stem cell maintenance
GO:0034427 IEA nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
GO:0051306 IMP mitotic sister chromatid separation
GO:0090501 IDA RNA phosphodiester bond hydrolysis
GO:0090503 IEA RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1990074 ISS polyuridylation-dependent mRNA catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000033259 dis3l2 DIS3 mitotic control homolog (S. cerevisiae)-like 2 protein_coding Danio_rerio
ENSMUSG00000053333 Dis3l2 DIS3 mitotic control homolog (S. cerevisiae)-like 2 protein_coding Mus_musculus

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