C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin-like growth factor binding protein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000146674 IGFBP3 9606 - 7:45912245-45921874 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000275521 IGFBP3-001 45912598-45921274 protein_coding
  ENST00000381083 IGFBP3-020 45913805-45921251 protein_coding
  ENST00000381086 IGFBP3-008 45912245-45921272 protein_coding
  ENST00000417621 IGFBP3-019 45914470-45917426 protein_coding
  ENST00000428530 IGFBP3-018 45914101-45917397 protein_coding
  ENST00000448817 IGFBP3-014 45916572-45921874 protein_coding
  ENST00000460209 IGFBP3-017 45913773-45915325 retained_intron
  ENST00000460477 IGFBP3-016 45916996-45920867 retained_intron
  ENST00000465642 IGFBP3-015 45916621-45920415 processed_transcript
  ENST00000613132 IGFBP3-201 45912251-45921140 protein_coding
  ENST00000615754 IGFBP3-202 45914820-45921140 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000275521ENST00000381086ENST00000613132
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000275521 25.729±0.00 12.241±0.00 3.685±0.00 2.105±1.40 29.102±0.00 7.795±0.00 1.683±0.00 42.708±0.00 8.066±0.00 3.962±0.00 2.964±0.00 29.758±1.10 292.858±93.61 6.782±3.51
ENST00000381086 N/A N/A N/A N/A 6.327±0.00 5.186±0.00 1.039±0.00 10.092±0.00 5.834±0.00 3.145±0.00 0.541±0.00 27.371±21.08 692.691±400.35 1.098±0.00
ENST00000613132 N/A 8.124±0.00 6.560±0.00 2.438±0.59 19.164±0.00 1.945±0.00 1.057±0.00 48.209±0.00 9.208±0.00 3.643±1.70 N/A 118.840±0.00 128.123±0.00 1.915±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005P5 CIL_0005P5_0002 CGP 7:45888357-45921874
CIL_0000S7 CIL_0000S7_0001 CGP 7:45912245-47582558

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 IEA regulation of cell growth
GO:0001649 IEA osteoblast differentiation
GO:0001933 IDA negative regulation of protein phosphorylation
GO:0001968 IEA fibronectin binding
GO:0005515 IPI protein binding
GO:0005520 NAS:IEA insulin-like growth factor binding
GO:0005576 NAS:IEA extracellular region
GO:0005615 IDA extracellular space
GO:0005634 IDA nucleus
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0008160 IDA protein tyrosine phosphatase activator activity
GO:0008285 IGI negative regulation of cell proliferation
GO:0009968 NAS negative regulation of signal transduction
GO:0010906 IEA regulation of glucose metabolic process
GO:0014912 IDA negative regulation of smooth muscle cell migration
GO:0016942 IC insulin-like growth factor binding protein complex
GO:0031994 IPI insulin-like growth factor I binding
GO:0040008 IEA regulation of growth
GO:0043065 IMP positive regulation of apoptotic process
GO:0043085 IDA positive regulation of catalytic activity
GO:0043410 IEA positive regulation of MAPK cascade
GO:0043568 IEA positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044267 TAS cellular protein metabolic process
GO:0044342 IEA type B pancreatic cell proliferation
GO:0045663 IDA positive regulation of myoblast differentiation
GO:0046872 NAS metal ion binding
GO:0048662 IDA negative regulation of smooth muscle cell proliferation
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014859 igfbp3 insulin-like growth factor binding protein 3 protein_coding Danio_rerio
ENSMUSG00000020427 Igfbp3 insulin-like growth factor binding protein 3 protein_coding Mus_musculus

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