C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: insulin-like growth factor binding protein 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020427 Igfbp3 10090 - 11:7206086-7213923 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020702 Igfbp3-001 7206086-7213897 protein_coding
  ENSMUST00000135887 Igfbp3-002 7207686-7213923 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020702ENSMUST00000135887
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020702 58.461±29.50 16.370±5.09 29.691±0.80 6.529±4.35 16.022±3.23 16.548±2.36 11.493±0.39 158.562±13.49 14.782±5.42 28.882±1.52 6.701±0.62 20.128±5.30 12.581±10.45 0.982±0.46
ENSMUST00000135887 4.445±0.00 94.450±20.90 N/A 1.973±0.90 22.969±9.43 26.867±7.00 N/A 65.644±0.00 4.279±1.38 14.717±10.63 N/A 52.278±12.48 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008WT CIL_0008WT_0002 VISTA 11:6754211-7357799
CIL_0005P5 CIL_0005P5_0003 CGP 11:7197782-7213923
CIL_0000S7 CIL_0000S7_0002 CGP 11:7206086-8664535

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001558 IGI regulation of cell growth
GO:0001649 IEP osteoblast differentiation
GO:0001933 ISO negative regulation of protein phosphorylation
GO:0001968 IDA fibronectin binding
GO:0005515 IEA protein binding
GO:0005520 IPI insulin-like growth factor binding
GO:0005615 IDA extracellular space
GO:0005634 ISO nucleus
GO:0006468 ISO protein phosphorylation
GO:0008160 ISS protein tyrosine phosphatase activator activity
GO:0008285 IEA negative regulation of cell proliferation
GO:0010906 IGI regulation of glucose metabolic process
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0031994 IEA insulin-like growth factor I binding
GO:0040008 IGI regulation of growth
GO:0043065 ISS positive regulation of apoptotic process
GO:0043085 IEA positive regulation of catalytic activity
GO:0043410 IGI positive regulation of MAPK cascade
GO:0043568 IGI positive regulation of insulin-like growth factor receptor signaling pathway
GO:0044342 IGI type B pancreatic cell proliferation
GO:0045663 ISS positive regulation of myoblast differentiation
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0070062 IEA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014859 igfbp3 insulin-like growth factor binding protein 3 protein_coding Danio_rerio
ENSG00000146674 IGFBP3 insulin-like growth factor binding protein 3 protein_coding Homo_sapiens

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