C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: malate dehydrogenase 2, NAD (mitochondrial)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000146701 MDH2 9606 + 7:76048051-76067508 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000315758 MDH2-001 76048067-76067508 protein_coding
  ENST00000424167 MDH2-007 76060368-76065173 retained_intron
  ENST00000432020 MDH2-002 76048161-76067067 protein_coding
  ENST00000443006 MDH2-004 76048085-76067506 protein_coding
  ENST00000461263 MDH2-003 76048051-76049047 protein_coding
  ENST00000461665 MDH2-006 76048136-76058175 retained_intron
  ENST00000490105 MDH2-008 76048161-76057447 processed_transcript
  ENST00000492663 MDH2-005 76054504-76057460 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000315758ENST00000424167ENST00000432020ENST00000443006ENST00000461665
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000315758 N/A 12.733±0.00 4.745±0.00 19.394±4.13 4.750±0.22 12.352±3.06 5.516±0.00 13.838±8.50 9.732±3.80 2.940±0.00 52.294±0.00 18.776±9.99 12.143±0.00 7.471±1.54
ENST00000424167 N/A 29.332±0.00 N/A N/A N/A 28.404±0.00 N/A 50.340±0.00 N/A N/A N/A N/A N/A N/A
ENST00000432020 34.957±0.00 31.985±0.00 N/A 37.710±0.00 30.236±0.00 32.854±0.00 51.542±48.18 23.538±14.60 19.519±0.00 16.935±0.00 41.482±0.00 33.155±26.43 27.580±13.38 28.461±1.44
ENST00000443006 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.286±0.00 N/A 1.379±0.00 N/A N/A
ENST00000461665 N/A N/A N/A N/A N/A N/A N/A N/A 76.800±0.00 N/A 273.314±0.00 7.087±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006NU CIL_0006NU_0001 CGP 7:75996338-76067508
CIL_0006NT CIL_0006NT_0001 CGP 7:76048051-76287288

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003824 IEA catalytic activity
GO:0005515 IEA protein binding
GO:0005634 IDA nucleus
GO:0005739 IDA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005759 TAS mitochondrial matrix
GO:0005886 IDA plasma membrane
GO:0005975 TAS:IEA carbohydrate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006094 TAS gluconeogenesis
GO:0006099 TAS tricarboxylic acid cycle
GO:0006107 IEA oxaloacetate metabolic process
GO:0006108 IDA:IEA malate metabolic process
GO:0006475 IDA internal protein amino acid acetylation
GO:0006734 IEA NADH metabolic process
GO:0016491 IEA oxidoreductase activity
GO:0016615 IEA malate dehydrogenase activity
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 IEA:IDA L-malate dehydrogenase activity
GO:0043621 IEA protein self-association
GO:0044237 TAS cellular metabolic process
GO:0044262 IEA cellular carbohydrate metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0044822 IDA poly(A) RNA binding
GO:0046554 IEA malate dehydrogenase (NADP+) activity
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000043371 mdh2 malate dehydrogenase 2, NAD (mitochondrial) protein_coding Danio_rerio
ENSMUSG00000019179 Mdh2 malate dehydrogenase 2, NAD (mitochondrial) protein_coding Mus_musculus

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