C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase inhibitor 2A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000147889 CDKN2A 9606 - 9:21967753-21995301 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000304494 CDKN2A-001 21967753-21975098 protein_coding
  ENST00000361570 CDKN2A-201 21967753-21994491 protein_coding
  ENST00000380150 CDKN2A-011 21970442-21971332 processed_transcript
  ENST00000380151 CDKN2A-003 21968180-21974827 nonsense_mediated_decay
  ENST00000470819 CDKN2A-007 21989340-21994873 processed_transcript
  ENST00000479692 CDKN2A-008 21969569-21971346 protein_coding
  ENST00000494262 CDKN2A-005 21968182-21995269 protein_coding
  ENST00000497750 CDKN2A-010 21970716-21971400 protein_coding
  ENST00000498124 CDKN2A-009 21968056-21974866 protein_coding
  ENST00000498628 CDKN2A-006 21968105-21995301 protein_coding
  ENST00000530628 CDKN2A-013 21968001-21994411 protein_coding
  ENST00000577854 CDKN2A-002 21969583-21970467 processed_transcript
  ENST00000578845 CDKN2A-015 21967996-21971332 protein_coding
  ENST00000579122 CDKN2A-014 21967991-21974858 protein_coding
  ENST00000579755 CDKN2A-004 21967753-21994624 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; OvaryENST00000578845
Transcript ID Ovary
ENST00000578845 173.662±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007YE CIL_0007YE_0001 VISTA 9:21773412-22380489
CIL_0007U7 CIL_0007U7_0001 VISTA 9:21778886-22382106
CIL_0007YH CIL_0007YH_0001 VISTA 9:21779916-22382548
CIL_0007YG CIL_0007YG_0001 VISTA 9:21783894-22389830
CIL_0007U8 CIL_0007U8_0001 VISTA 9:21787553-22389799
CIL_00095D CIL_00095D_0001 VISTA 9:21788649-22389830
CIL_000945 CIL_000945_0001 VISTA 9:21789705-22397955
CIL_0008WE CIL_0008WE_0001 VISTA 9:21797850-22401302
CIL_0007YC CIL_0007YC_0001 VISTA 9:21801286-22408086
CIL_00099P CIL_00099P_0001 VISTA 9:21802665-22404754
CIL_0008P9 CIL_0008P9_0001 VISTA 9:21802671-22404650
CIL_00099O CIL_00099O_0001 VISTA 9:21806995-22409801
CIL_0008TL CIL_0008TL_0001 VISTA 9:21807568-22413901
CIL_00094Y CIL_00094Y_0001 VISTA 9:21816988-22419575
CIL_0008SY CIL_0008SY_0001 VISTA 9:21818504-22425326
CIL_0008T0 CIL_0008T0_0001 VISTA 9:21825013-22425357
CIL_00085X CIL_00085X_0001 VISTA 9:21825358-22430491
CIL_00094Z CIL_00094Z_0001 VISTA 9:21827678-22430449
CIL_0008GG CIL_0008GG_0001 VISTA 9:21841068-22443944

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 IDA G1/S transition of mitotic cell cycle
GO:0000209 IDA protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0001953 IMP negative regulation of cell-matrix adhesion
GO:0002039 IPI p53 binding
GO:0003677 IEA DNA binding
GO:0004861 IDA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006364 IEA rRNA processing
GO:0006469 IMP negative regulation of protein kinase activity
GO:0006919 IMP activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007050 IDA cell cycle arrest
GO:0007265 IEP Ras protein signal transduction
GO:0008134 IPI transcription factor binding
GO:0008285 IDA negative regulation of cell proliferation
GO:0008637 IMP apoptotic mitochondrial changes
GO:0010389 IMP regulation of G2/M transition of mitotic cell cycle
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0016604 IDA nuclear body
GO:0019901 IPI protein kinase binding
GO:0030308 IDA negative regulation of cell growth
GO:0030889 ISS negative regulation of B cell proliferation
GO:0031647 ISS regulation of protein stability
GO:0031648 IDA protein destabilization
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0033088 ISS negative regulation of immature T cell proliferation in thymus
GO:0033235 IMP positive regulation of protein sumoylation
GO:0034393 ISS positive regulation of smooth muscle cell apoptotic process
GO:0035985 IDA senescence-associated heterochromatin focus
GO:0035986 IMP senescence-associated heterochromatin focus assembly
GO:0042326 IDA negative regulation of phosphorylation
GO:0043234 IDA protein complex
GO:0043517 IDA positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044822 IDA poly(A) RNA binding
GO:0045736 IDA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046825 IMP regulation of protein export from nucleus
GO:0048103 ISS somatic stem cell division
GO:0050821 IDA protein stabilization
GO:0051059 IDA NF-kappaB binding
GO:0051444 ISS negative regulation of ubiquitin-protein transferase activity
GO:0055105 ISS ubiquitin-protein transferase inhibitor activity
GO:0070534 IDA protein K63-linked ubiquitination
GO:0071158 IDA positive regulation of cell cycle arrest
GO:0090398 IMP cellular senescence
GO:0090399 IMP replicative senescence
GO:0097371 IPI MDM2/MDM4 family protein binding
GO:1902510 IMP regulation of apoptotic DNA fragmentation
GO:2000111 ISS positive regulation of macrophage apoptotic process
GO:2000774 IMP positive regulation of cellular senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037262 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) protein_coding Danio_rerio

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