C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: neurotrophic tyrosine kinase, receptor, type 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000359847 NTRK2-005 ENSG00000148053 9606 + 9:84670660-84815702 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359847
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359847 2.266±0.00 4.529±0.00 7.015±0.00 57.660±12.18 5.999±0.43 1.395±0.40 1.229±0.11 3.574±2.99 6.342±0.00 1.207±0.07 0.759±0.41 3.258±2.56 0.420±0.19 5.041±3.66

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006HO CIL_0006HO_0001 CGP 9:84275457-85027070
CIL_00007E CIL_00007E_0002 CGP 9:84668551-85742029

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001764 ISS neuron migration
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005887 IDA integral component of plasma membrane
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007190 TAS activation of adenylate cyclase activity
GO:0007612 ISS learning
GO:0008284 ISS positive regulation of cell proliferation
GO:0010628 ISS positive regulation of gene expression
GO:0010976 ISS positive regulation of neuron projection development
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0021954 ISS central nervous system neuron development
GO:0021987 ISS cerebral cortex development
GO:0030182 ISS neuron differentiation
GO:0031547 IMP brain-derived neurotrophic factor receptor signaling pathway
GO:0032314 ISS regulation of Rac GTPase activity
GO:0042803 ISS protein homodimerization activity
GO:0043121 ISS neurotrophin binding
GO:0043235 IDA receptor complex
GO:0043410 ISS positive regulation of MAPK cascade
GO:0043524 ISS negative regulation of neuron apoptotic process
GO:0046777 ISS protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048403 ISS brain-derived neurotrophic factor binding
GO:0050772 ISS positive regulation of axonogenesis
GO:0060175 IMP brain-derived neurotrophic factor-activated receptor activity

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000109838 Ntrk2-202 protein_coding Mus_musculus 0 1884
ENSMUST00000079828 Ntrk2-201 protein_coding Mus_musculus 0 1592

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