C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: checkpoint kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032113 Chek1 10090 - 9:36708482-36727065 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034625 Chek1-201 36708482-36726658 protein_coding
  ENSMUST00000172702 Chek1-002 36708482-36726374 protein_coding
  ENSMUST00000172742 Chek1-003 36723862-36726451 protein_coding
  ENSMUST00000173534 Chek1-006 36710157-36725868 protein_coding
  ENSMUST00000173796 Chek1-008 36722649-36727065 processed_transcript
  ENSMUST00000173963 Chek1-005 36710157-36725868 protein_coding
  ENSMUST00000173977 Chek1-009 36723603-36726570 retained_intron
  ENSMUST00000174105 Chek1-004 36709440-36726585 nonsense_mediated_decay
  ENSMUST00000174794 Chek1-010 36713744-36722745 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000034625ENSMUST00000172702ENSMUST00000172742ENSMUST00000173534ENSMUST00000173796ENSMUST00000173963ENSMUST00000173977ENSMUST00000174105ENSMUST00000174794
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000034625 0.380±0.00 N/A 0.173±0.08 0.599±0.44 0.071±0.03 0.306±0.12 N/A 0.097±0.04 3.599±2.15 0.112±0.03 0.027±0.01 0.812±0.24 1.860±1.19 0.360±0.04
ENSMUST00000172702 0.052±0.00 0.212±0.07 0.100±0.00 0.116±0.07 0.071±0.00 0.145±0.05 0.086±0.01 N/A 0.059±0.00 0.109±0.07 N/A 0.570±0.45 0.537±0.00 0.268±0.00
ENSMUST00000172742 N/A N/A N/A 3.283±0.00 N/A N/A N/A N/A N/A N/A N/A 53.976±0.00 106.213±0.00 17.842±0.00
ENSMUST00000173534 N/A N/A N/A 0.082±0.00 N/A N/A N/A 0.096±0.00 N/A N/A 0.075±0.00 3.427±0.00 N/A N/A
ENSMUST00000173796 0.385±0.22 0.221±0.11 N/A 0.486±0.00 0.221±0.17 0.469±0.20 0.161±0.01 0.219±0.08 0.149±0.07 0.318±0.13 0.095±0.03 0.520±0.17 N/A 3.615±1.27
ENSMUST00000173963 0.484±0.06 0.474±0.24 N/A 0.150±0.00 0.026±0.00 0.485±0.18 N/A 0.088±0.02 0.149±0.08 0.132±0.00 0.057±0.01 2.127±1.62 5.557±1.50 1.262±0.16
ENSMUST00000173977 N/A N/A N/A N/A N/A N/A N/A N/A 0.282±0.00 N/A N/A 0.959±0.00 N/A N/A
ENSMUST00000174105 0.102±0.00 N/A 0.407±0.06 1.617±0.83 0.244±0.15 N/A 0.051±0.02 0.130±0.00 3.311±1.91 0.056±0.00 0.084±0.03 2.406±0.98 2.278±0.96 1.114±0.29
ENSMUST00000174794 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.125±0.05 N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IMP DNA damage checkpoint
GO:0000086 IMP G2/M transition of mitotic cell cycle
GO:0000781 IEA chromosome, telomeric region
GO:0000785 IDA chromatin
GO:0000794 ISS condensed nuclear chromosome
GO:0004672 IMP protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005615 IEA extracellular space
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005657 IDA replication fork
GO:0005737 IEA cytoplasm
GO:0005813 ISS centrosome
GO:0006281 IDA DNA repair
GO:0006468 IDA protein phosphorylation
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0006975 ISS DNA damage induced protein phosphorylation
GO:0010468 IGI regulation of gene expression
GO:0010569 ISS regulation of double-strand break repair via homologous recombination
GO:0010767 IMP regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0010972 IEA negative regulation of G2/M transition of mitotic cell cycle
GO:0018107 ISS peptidyl-threonine phosphorylation
GO:0031572 ISS G2 DNA damage checkpoint
GO:0035402 IDA histone kinase activity (H3-T11 specific)
GO:0035407 IDA histone H3-T11 phosphorylation
GO:0042127 IMP regulation of cell proliferation
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0045839 ISS negative regulation of mitosis
GO:0046602 ISS regulation of mitotic centrosome separation
GO:0048096 IMP chromatin-mediated maintenance of transcription
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071310 IEA cellular response to organic substance
GO:0071313 IEA cellular response to caffeine
GO:2000279 IEA negative regulation of DNA biosynthetic process
GO:2000615 IDA regulation of histone H3-K9 acetylation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014385 chek1 CHK1 checkpoint homolog (S. pombe) protein_coding Danio_rerio
ENSG00000149554 CHEK1 checkpoint kinase 1 protein_coding Homo_sapiens

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