C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type II, beta subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149575 SCN2B 9606 - 11:118161951-118176673 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000278947 SCN2B-001 118161951-118176673 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000278947
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000278947 0.053±0.00 0.301±0.00 0.037±0.00 13.785±6.98 0.292±0.08 1.078±1.05 1.156±0.45 0.340±0.00 0.066±0.05 0.248±0.16 0.534±0.12 0.287±0.25 0.046±0.03 0.333±0.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081E CIL_00081E_0001 VISTA 11:118137591-118740525

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IDA voltage-gated sodium channel complex
GO:0005248 IEA voltage-gated sodium channel activity
GO:0005515 IEA protein binding
GO:0007268 TAS synaptic transmission
GO:0007399 IEA nervous system development
GO:0017080 IDA sodium channel regulator activity
GO:0035725 IDA sodium ion transmembrane transport
GO:0046684 IEA response to pyrethroid
GO:0060048 IMP cardiac muscle contraction
GO:0060371 IMP regulation of atrial cardiac muscle cell membrane depolarization
GO:0086002 IMP cardiac muscle cell action potential involved in contraction
GO:0086006 IMP voltage-gated sodium channel activity involved in cardiac muscle cell action potential
GO:0086012 IMP membrane depolarization during cardiac muscle cell action potential
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:2000649 IDA regulation of sodium ion transmembrane transporter activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041176 scn2b sodium channel, voltage-gated, type II, beta protein_coding Danio_rerio
ENSMUSG00000070304 Scn2b sodium channel, voltage-gated, type II, beta protein_coding Mus_musculus

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