C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inositol 1,4,5-trisphosphate receptor, type 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000150995 ITPR1 9606 + 3:4493348-4847840 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302640 ITPR1-201 4493348-4847840 protein_coding
  ENST00000354582 ITPR1-202 4493348-4847840 protein_coding
  ENST00000357086 ITPR1-001 4493350-4847602 protein_coding
  ENST00000443694 ITPR1-004 4516492-4847395 protein_coding
  ENST00000456211 ITPR1-002 4493350-4847602 protein_coding
  ENST00000463980 ITPR1-011 4799799-4846861 processed_transcript
  ENST00000467056 ITPR1-003 4493350-4646008 retained_intron
  ENST00000467545 ITPR1-018 4795000-4811306 retained_intron
  ENST00000472205 ITPR1-019 4813047-4818239 retained_intron
  ENST00000477577 ITPR1-005 4639375-4671786 processed_transcript
  ENST00000478515 ITPR1-020 4814645-4836948 retained_intron
  ENST00000479831 ITPR1-015 4768267-4775334 retained_intron
  ENST00000481415 ITPR1-016 4782340-4787991 retained_intron
  ENST00000487016 ITPR1-013 4724377-4735625 retained_intron
  ENST00000490572 ITPR1-017 4800205-4811460 processed_transcript
  ENST00000491868 ITPR1-012 4596063-4639409 processed_transcript
  ENST00000493491 ITPR1-010 4799795-4846463 processed_transcript
  ENST00000494681 ITPR1-014 4711586-4735210 retained_intron
  ENST00000544951 ITPR1-203 4493348-4847840 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000302640ENST00000354582ENST00000357086ENST00000443694ENST00000456211ENST00000463980ENST00000472205ENST00000493491
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000302640 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.073±0.00 N/A N/A N/A
ENST00000354582 N/A N/A 4.967±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000357086 3.469±0.00 1.219±0.00 3.968±0.02 1.681±0.00 1.104±0.00 1.401±0.49 0.141±0.00 13.144±0.00 5.847±0.00 N/A 2.783±1.40 0.955±0.56 3.226±0.00
ENST00000443694 N/A N/A 5.857±0.27 1.100±0.00 1.135±0.45 1.009±0.00 1.931±1.60 N/A 1.953±0.00 0.412±0.00 0.252±0.00 1.274±0.30 1.580±0.59
ENST00000456211 1.117±0.00 3.647±0.00 N/A 2.545±0.00 1.927±0.00 0.702±0.00 N/A 1.749±1.45 2.345±0.00 0.448±0.00 2.183±1.42 N/A 0.519±0.00
ENST00000463980 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.502±0.00 0.956±0.00 1.748±0.58 N/A
ENST00000472205 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.335±0.00 N/A N/A N/A
ENST00000493491 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.650±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00050D CIL_00050D_0001 CGP 3:4493348-4985323

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0005216 IEA ion channel activity
GO:0005218 ISS intracellular ligand-gated calcium channel activity
GO:0005220 ISS inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 IEA calcium channel activity
GO:0005515 IPI protein binding
GO:0005635 IEA nuclear envelope
GO:0005637 IEA nuclear inner membrane
GO:0005730 IEA nucleolus
GO:0005737 IEA cytoplasm
GO:0005783 NAS endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005955 IEA calcineurin complex
GO:0006112 TAS energy reserve metabolic process
GO:0006811 IEA ion transport
GO:0006816 NAS calcium ion transport
GO:0007165 NAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007596 TAS blood coagulation
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009791 IEA post-embryonic development
GO:0014069 IEA postsynaptic density
GO:0015085 TAS calcium ion transmembrane transporter activity
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016529 IEA sarcoplasmic reticulum
GO:0019855 IDA calcium channel inhibitor activity
GO:0030168 TAS platelet activation
GO:0031088 IDA platelet dense granule membrane
GO:0031094 IDA platelet dense tubular network
GO:0031095 TAS platelet dense tubular network membrane
GO:0032469 IEA endoplasmic reticulum calcium ion homeostasis
GO:0034220 IEA ion transmembrane transport
GO:0035091 ISS phosphatidylinositol binding
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043234 IEA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0045087 TAS innate immune response
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048016 IEA inositol phosphate-mediated signaling
GO:0050796 TAS regulation of insulin secretion
GO:0050849 IDA negative regulation of calcium-mediated signaling
GO:0050882 IEA voluntary musculoskeletal movement
GO:0051209 ISS release of sequestered calcium ion into cytosol
GO:0055085 IEA transmembrane transport
GO:0070059 ISS intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588 IEA calcium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014655 itpr1a inositol 1,4,5-triphosphate receptor, type 1a protein_coding Danio_rerio
ENSDARG00000074149 ITPR1 (2 of 2) inositol 1,4,5-trisphosphate receptor, type 1 protein_coding Danio_rerio
ENSMUSG00000030102 Itpr1 inositol 1,4,5-trisphosphate receptor 1 protein_coding Mus_musculus

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