C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inositol 1,4,5-trisphosphate receptor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030102 Itpr1 10090 + 6:108213118-108551109 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000032192 Itpr1-201 108213118-108551109 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000032192
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000032192 4.702±2.00 4.502±0.87 15.239±0.00 23.731±23.45 4.467±0.81 3.395±0.70 3.176±0.99 12.755±0.00 2.190±0.81 7.746±2.85 1.586±0.19 9.635±3.12 1.183±0.88 1.850±0.27

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004TR CIL_0004TR_0002 CGP 6:108107028-108551109
CIL_00050D CIL_00050D_0002 CGP 6:108213118-108666925

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001666 IDA response to hypoxia
GO:0005218 IDA intracellular ligand-gated calcium channel activity
GO:0005220 TAS inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005515 IPI protein binding
GO:0005635 IDA nuclear envelope
GO:0005637 IDA nuclear inner membrane
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005783 TAS endoplasmic reticulum
GO:0005789 IDA endoplasmic reticulum membrane
GO:0005955 IDA calcineurin complex
GO:0006816 IDA calcium ion transport
GO:0009791 IMP post-embryonic development
GO:0014069 IDA postsynaptic density
GO:0016021 IEA integral component of membrane
GO:0016529 IDA sarcoplasmic reticulum
GO:0019855 IEA calcium channel inhibitor activity
GO:0031088 IEA platelet dense granule membrane
GO:0031094 IEA platelet dense tubular network
GO:0032469 IGI endoplasmic reticulum calcium ion homeostasis
GO:0035091 IDA phosphatidylinositol binding
GO:0043234 IPI protein complex
GO:0048016 IEA inositol phosphate-mediated signaling
GO:0050849 IEA negative regulation of calcium-mediated signaling
GO:0050882 IMP voluntary musculoskeletal movement
GO:0051209 IMP release of sequestered calcium ion into cytosol
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588 IEA calcium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014655 itpr1a inositol 1,4,5-triphosphate receptor, type 1a protein_coding Danio_rerio
ENSDARG00000074149 ITPR1 (2 of 2) inositol 1,4,5-trisphosphate receptor, type 1 protein_coding Danio_rerio
ENSG00000150995 ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 protein_coding Homo_sapiens

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