C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: phosphodiesterase 3B, cGMP-inhibited
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152270 PDE3B 9606 + 11:14643723-14872044 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000282096 PDE3B-001 14643723-14872044 protein_coding
  ENST00000455098 PDE3B-002 14643831-14869894 protein_coding
  ENST00000525439 PDE3B-004 14788939-14819206 processed_transcript
  ENST00000532740 PDE3B-005 14698839-14700926 processed_transcript
  ENST00000534317 PDE3B-003 14644260-14776663 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000282096ENST00000455098ENST00000525439ENST00000532740ENST00000534317
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000282096 10.298±0.00 1.056±0.00 0.437±0.00 0.792±0.04 10.259±6.41 4.689±0.25 1.081±0.06 2.639±2.28 5.526±0.75 2.893±0.37 0.013±0.00 0.660±0.59 0.926±0.17 4.387±0.49
ENST00000455098 4.975±0.00 0.367±0.00 N/A N/A 7.027±3.20 N/A 0.583±0.00 4.255±0.00 N/A N/A 0.184±0.00 0.341±0.17 0.547±0.12 4.101±1.96
ENST00000525439 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.097±0.00 N/A N/A N/A
ENST00000532740 0.109±0.00 0.047±0.00 N/A 0.403±0.00 3.037±0.00 N/A N/A 1.474±0.00 N/A 6.088±0.00 N/A 2.108±0.00 0.036±0.00 0.068±0.00
ENST00000534317 N/A 0.159±0.00 1.298±0.00 0.761±0.00 2.767±0.00 2.239±0.00 0.910±0.00 N/A 4.264±0.00 3.668±0.00 0.062±0.06 1.000±0.74 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003ZT CIL_0003ZT_0001 CGP 11:14504874-14872044
CIL_0003ZS CIL_0003ZS_0001 CGP 11:14643723-14892252

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0004114 TAS:IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004119 TAS cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
GO:0005515 IPI protein binding
GO:0005783 ISS endoplasmic reticulum
GO:0005794 ISS Golgi apparatus
GO:0005829 TAS cytosol
GO:0006198 IEP cAMP catabolic process
GO:0007162 IMP negative regulation of cell adhesion
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016525 IMP negative regulation of angiogenesis
GO:0031018 IEA endocrine pancreas development
GO:0032045 IDA guanyl-nucleotide exchange factor complex
GO:0032869 ISS cellular response to insulin stimulus
GO:0033629 IC negative regulation of cell adhesion mediated by integrin
GO:0042593 IEA glucose homeostasis
GO:0043422 ISS protein kinase B binding
GO:0043951 IC negative regulation of cAMP-mediated signaling
GO:0046872 IEA metal ion binding
GO:0050796 IEA regulation of insulin secretion
GO:0050995 IMP negative regulation of lipid catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062190 PDE3B phosphodiesterase 3B, cGMP-inhibited protein_coding Danio_rerio
ENSMUSG00000030671 Pde3b phosphodiesterase 3B, cGMP-inhibited protein_coding Mus_musculus

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