C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000152689 RASGRP3 9606 + 2:33436324-33564750 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000402538 RASGRP3-001 33436324-33564750 protein_coding
  ENST00000403687 RASGRP3-006 33476228-33564731 protein_coding
  ENST00000407811 RASGRP3-004 33513875-33564605 protein_coding
  ENST00000419772 RASGRP3-019 33527203-33539989 nonsense_mediated_decay
  ENST00000423159 RASGRP3-013 33476649-33520656 protein_coding
  ENST00000425210 RASGRP3-008 33476649-33516573 protein_coding
  ENST00000437184 RASGRP3-007 33458046-33522102 protein_coding
  ENST00000442390 RASGRP3-012 33476623-33520009 protein_coding
  ENST00000444784 RASGRP3-014 33476649-33520653 protein_coding
  ENST00000468856 RASGRP3-005 33531725-33540181 retained_intron
  ENST00000477927 RASGRP3-018 33524430-33530944 processed_transcript
  ENST00000479528 RASGRP3-010 33436567-33516693 retained_intron
  ENST00000482731 RASGRP3-020 33539651-33543627 processed_transcript
  ENST00000482857 RASGRP3-011 33476597-33516788 retained_intron
  ENST00000484909 RASGRP3-002 33436326-33482936 retained_intron
  ENST00000490150 RASGRP3-017 33527181-33539349 retained_intron
  ENST00000494927 RASGRP3-015 33476665-33482014 retained_intron
  ENST00000497723 RASGRP3-009 33436413-33511842 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000402538ENST00000403687ENST00000407811ENST00000425210ENST00000437184ENST00000468856ENST00000479528ENST00000484909
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000402538 1.279±0.00 N/A N/A N/A 0.819±0.00 0.365±0.00 1.329±0.00 N/A 0.682±0.00 1.579±0.00 N/A 0.568±0.15 1.417±0.48 0.239±0.00
ENST00000403687 N/A 1.324±0.00 N/A 1.656±0.24 0.610±0.00 N/A N/A 0.558±0.00 0.340±0.00 0.971±0.00 1.793±0.00 0.384±0.00 0.382±0.12 0.084±0.00
ENST00000407811 0.441±0.00 3.444±0.00 1.530±0.00 2.494±1.45 1.656±0.33 0.846±0.31 1.414±0.57 1.355±0.40 0.566±0.00 0.768±0.00 1.059±0.00 1.138±0.19 1.183±0.99 0.405±0.19
ENST00000425210 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.974±0.00 N/A N/A N/A
ENST00000437184 N/A N/A N/A N/A N/A N/A 5.034±0.00 N/A 2.348±0.00 N/A 5.451±0.00 2.951±0.00 N/A N/A
ENST00000468856 N/A N/A N/A N/A N/A N/A N/A 0.175±0.00 N/A 0.721±0.00 N/A N/A N/A 0.140±0.00
ENST00000479528 N/A N/A 7.336±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000484909 N/A N/A N/A N/A N/A N/A N/A 0.516±0.00 1.005±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MZ CIL_0000MZ_0001 CGP 2:32946972-33564750
CIL_0003TB CIL_0003TB_0002 CGP 2:33436324-33599382

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 NAS MAPK cascade
GO:0004871 TAS signal transducer activity
GO:0005085 TAS:IEA guanyl-nucleotide exchange factor activity
GO:0005088 IEA Ras guanyl-nucleotide exchange factor activity
GO:0005099 IEA Ras GTPase activator activity
GO:0005509 NAS:IEA calcium ion binding
GO:0005622 IEA intracellular
GO:0005737 IEA cytoplasm
GO:0005886 TAS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0007264 TAS:IEA small GTPase mediated signal transduction
GO:0007265 IEA Ras protein signal transduction
GO:0017016 IEA Ras GTPase binding
GO:0019900 IEA kinase binding
GO:0019992 NAS diacylglycerol binding
GO:0032045 IEA guanyl-nucleotide exchange factor complex
GO:0032320 IEA positive regulation of Ras GTPase activity
GO:0032854 IDA positive regulation of Rap GTPase activity
GO:0035556 IEA intracellular signal transduction
GO:0043087 IEA regulation of GTPase activity
GO:0043547 TAS positive regulation of GTPase activity
GO:0046582 IDA Rap GTPase activator activity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051056 IEA regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077864 rasgrp3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) protein_coding Danio_rerio
ENSMUSG00000071042 Rasgrp3 RAS, guanyl releasing protein 3 protein_coding Mus_musculus

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