C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proteasome (prosome, macropain) subunit, alpha type, 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000154611 PSMA8 9606 + 18:26133852-26193355 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000308268 PSMA8-001 26133877-26193355 protein_coding
  ENST00000343848 PSMA8-003 26133874-26193355 protein_coding
  ENST00000415576 PSMA8-002 26133852-26192824 protein_coding
  ENST00000538664 PSMA8-004 26133852-26193355 nonsense_mediated_decay
  ENST00000612461 PSMA8-201 26140086-26193355 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastHeartOvaryPlacentaTestisENST00000308268ENST00000343848ENST00000415576ENST00000612461
Transcript ID Adipose Adrenal Brain Breast Heart Ovary Placenta Testis
ENST00000308268 N/A N/A N/A N/A N/A 0.011±0.00 N/A 1.029±0.00
ENST00000343848 0.045±0.00 0.073±0.00 N/A N/A 0.060±0.00 0.011±0.00 0.074±0.00 1.265±0.00
ENST00000415576 N/A N/A 0.039±0.00 0.070±0.02 N/A 0.029±0.00 0.245±0.14 7.968±5.83
ENST00000612461 N/A N/A N/A N/A N/A 0.008±0.01 0.122±0.06 3.044±0.97

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007LU CIL_0007LU_0001 UCNEbase 18:24628254-26687255
CIL_0008CS CIL_0008CS_0001 VISTA 18:25552759-26154861
CIL_0006ET CIL_0006ET_0001 CGP 18:26016253-26193355
CIL_0000QZ CIL_0000QZ_0001 CGP 18:26133852-26391685

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 TAS protein polyubiquitination
GO:0000278 TAS mitotic cell cycle
GO:0002474 TAS antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 IEA endopeptidase activity
GO:0004298 IEA threonine-type endopeptidase activity
GO:0005634 IDA nucleus
GO:0005829 TAS cytosol
GO:0005839 IEA proteasome core complex
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006521 TAS regulation of cellular amino acid metabolic process
GO:0006915 TAS apoptotic process
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 TAS gene expression
GO:0016032 TAS viral process
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0019773 IEA proteasome core complex, alpha-subunit complex
GO:0031145 TAS anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0042590 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 TAS regulation of apoptotic process
GO:0043066 TAS negative regulation of apoptotic process
GO:0044281 TAS small molecule metabolic process
GO:0051437 TAS positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 IEA proteolysis involved in cellular protein catabolic process
GO:0070062 IDA extracellular vesicular exosome
GO:1990111 ISS spermatoproteasome complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010965 psma8 proteasome (prosome, macropain) subunit, alpha type, 8 protein_coding Danio_rerio
ENSMUSG00000036743 Psma8 proteasome (prosome, macropain) subunit, alpha type, 8 protein_coding Mus_musculus

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