C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CCR4-NOT transcription complex, subunit 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000155508 CNOT8 9606 + 5:154857553-154876793 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000285896 CNOT8-001 154858546-154876793 protein_coding
  ENST00000403027 CNOT8-010 154858517-154876792 protein_coding
  ENST00000517568 CNOT8-015 154858537-154870704 protein_coding
  ENST00000517876 CNOT8-006 154858252-154876792 protein_coding
  ENST00000518028 CNOT8-018 154858635-154865240 protein_coding
  ENST00000518775 CNOT8-024 154858662-154875398 protein_coding
  ENST00000518782 CNOT8-017 154858241-154859439 processed_transcript
  ENST00000519211 CNOT8-013 154858482-154870705 protein_coding
  ENST00000519394 CNOT8-021 154858654-154865344 protein_coding
  ENST00000519404 CNOT8-003 154858652-154875478 protein_coding
  ENST00000519430 CNOT8-019 154858625-154865241 protein_coding
  ENST00000519903 CNOT8-012 154858517-154871831 protein_coding
  ENST00000520472 CNOT8-011 154858262-154870747 protein_coding
  ENST00000520671 CNOT8-007 154858627-154875458 protein_coding
  ENST00000521174 CNOT8-025 154857553-154863220 processed_transcript
  ENST00000521402 CNOT8-020 154859667-154867733 processed_transcript
  ENST00000521450 CNOT8-005 154858517-154875872 protein_coding
  ENST00000521583 CNOT8-008 154858627-154875585 protein_coding
  ENST00000521729 CNOT8-009 154858654-154875587 nonsense_mediated_decay
  ENST00000522139 CNOT8-022 154870444-154872582 retained_intron
  ENST00000522458 CNOT8-014 154858515-154871781 protein_coding
  ENST00000522644 CNOT8-023 154858689-154872648 nonsense_mediated_decay
  ENST00000523270 CNOT8-016 154858219-154859870 processed_transcript
  ENST00000523698 CNOT8-004 154858249-154875456 protein_coding
  ENST00000524105 CNOT8-002 154858539-154875513 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000285896ENST00000403027ENST00000517876ENST00000520671ENST00000521450ENST00000521729
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000285896 11.704±0.00 10.835±0.00 N/A 8.683±4.82 4.391±0.00 7.995±5.49 4.729±0.00 9.967±0.00 3.293±0.53 10.309±3.42 5.201±0.00 6.053±2.35 7.544±1.78 N/A
ENST00000403027 N/A 4.807±0.00 N/A N/A N/A 1.302±0.00 N/A N/A N/A 6.124±0.00 N/A 3.611±0.98 N/A N/A
ENST00000517876 7.376±0.00 N/A 1.580±0.00 3.336±0.00 N/A 4.999±0.00 3.226±0.00 3.972±0.00 N/A 5.834±0.00 N/A 3.939±0.17 4.783±2.09 11.808±0.02
ENST00000520671 N/A N/A N/A N/A N/A N/A N/A N/A 7.439±0.00 N/A N/A N/A N/A N/A
ENST00000521450 N/A N/A 4.241±0.00 N/A 9.556±0.00 3.708±0.00 3.121±0.00 N/A N/A 10.866±0.00 2.001±0.00 7.037±0.00 N/A 20.282±0.00
ENST00000521729 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.874±0.00 10.505±0.00 18.949±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00088D CIL_00088D_0001 VISTA 5:154298500-154906275
CIL_00023V CIL_00023V_0001 CGP 5:154857553-154938209

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000175 IDA 3'-5'-exoribonuclease activity
GO:0000288 TAS nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 TAS nuclear-transcribed mRNA poly(A) tail shortening
GO:0003676 IEA nucleic acid binding
GO:0003700 NAS sequence-specific DNA binding transcription factor activity
GO:0003723 IEA RNA binding
GO:0004535 IDA poly(A)-specific ribonuclease activity
GO:0005515 IPI protein binding
GO:0005622 IDA intracellular
GO:0005634 IEA:NAS nucleus
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 NAS regulation of transcription, DNA-templated
GO:0006417 IEA regulation of translation
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 TAS negative regulation of cell proliferation
GO:0010467 TAS gene expression
GO:0016070 TAS RNA metabolic process
GO:0016071 TAS mRNA metabolic process
GO:0030014 IDA CCR4-NOT complex
GO:0035195 TAS gene silencing by miRNA
GO:0043928 IDA exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0046872 IEA metal ion binding
GO:0090503 IEA RNA phosphodiester bond hydrolysis, exonucleolytic

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020043 cnot8 CCR4-NOT transcription complex, subunit 8 protein_coding Danio_rerio
ENSMUSG00000020515 Cnot8 CCR4-NOT transcription complex, subunit 8 protein_coding Mus_musculus

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