C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ADAM metallopeptidase with thrombospondin type 1 motif, 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000156140 ADAMTS3 9606 - 4:72280969-72568799 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000286657 ADAMTS3-001 72280969-72568799 protein_coding
  ENST00000505193 ADAMTS3-004 72441676-72568045 processed_transcript
  ENST00000511274 ADAMTS3-005 72298225-72312255 processed_transcript
  ENST00000622135 ADAMTS3-201 72282041-72568796 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastColonHeartKidneyLiverOvaryPlacentaTestisENST00000286657ENST00000505193ENST00000622135
Transcript ID Breast Colon Heart Kidney Liver Ovary Placenta Testis
ENST00000286657 0.179±0.00 N/A N/A 0.215±0.21 0.135±0.00 0.484±0.18 0.294±0.24 0.603±0.13
ENST00000505193 N/A 0.273±0.00 0.103±0.00 N/A N/A N/A N/A N/A
ENST00000622135 0.120±0.00 0.134±0.00 N/A N/A N/A 0.226±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000DB CIL_0000DB_0001 CGP 4:72031804-72568799
CIL_0000DC CIL_0000DC_0001 CGP 4:72280969-73069755

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IDA endopeptidase activity
GO:0004222 NAS:IEA metalloendopeptidase activity
GO:0005515 IPI protein binding
GO:0005576 TAS extracellular region
GO:0005578 NAS proteinaceous extracellular matrix
GO:0005615 IDA extracellular space
GO:0006508 IEA proteolysis
GO:0008201 IEA heparin binding
GO:0008233 IEA peptidase activity
GO:0008270 NAS:IEA zinc ion binding
GO:0010573 IDA vascular endothelial growth factor production
GO:0016485 IDA protein processing
GO:0030198 TAS extracellular matrix organization
GO:0030199 IC collagen fibril organization
GO:0030574 NAS collagen catabolic process
GO:0031012 TAS:IEA extracellular matrix
GO:0032964 IDA collagen biosynthetic process
GO:0043206 IC extracellular fibril organization
GO:0070062 IDA extracellular vesicular exosome
GO:1900748 IDA positive regulation of vascular endothelial growth factor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060127 adamts3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 protein_coding Danio_rerio
ENSMUSG00000043635 Adamts3 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 protein_coding Mus_musculus

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