C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000158571 PFKFB1 9606 - X:54932961-54998534 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000374992 PFKFB1-201 54933134-54994078 protein_coding
  ENST00000375006 PFKFB1-001 54932961-54994078 protein_coding
  ENST00000545676 PFKFB1-202 54933134-54998534 protein_coding
  ENST00000614686 PFKFB1-203 54933387-54994022 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000374992ENST00000375006ENST00000545676ENST00000614686
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000374992 N/A N/A N/A N/A N/A N/A N/A N/A 1.421±0.00 N/A N/A N/A 0.081±0.00 N/A
ENST00000375006 1.110±0.00 N/A 0.104±0.00 N/A N/A N/A 0.056±0.00 3.331±0.00 N/A N/A 1.483±0.00 0.063±0.00 N/A 0.314±0.00
ENST00000545676 0.953±0.00 N/A N/A N/A 6.561±0.00 0.080±0.00 N/A N/A N/A 0.099±0.00 1.344±0.08 0.032±0.00 0.020±0.00 0.294±0.00
ENST00000614686 N/A 0.043±0.00 0.342±0.00 0.025±0.00 3.213±0.00 N/A 0.023±0.00 0.421±0.00 N/A 0.066±0.00 1.873±0.00 0.100±0.08 0.083±0.00 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003873 IEA 6-phosphofructo-2-kinase activity
GO:0004331 IEA fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005829 TAS cytosol
GO:0005975 TAS carbohydrate metabolic process
GO:0006000 IEA fructose metabolic process
GO:0006003 IEA fructose 2,6-bisphosphate metabolic process
GO:0006006 TAS glucose metabolic process
GO:0006094 TAS gluconeogenesis
GO:0006096 TAS glycolytic process
GO:0006112 TAS energy reserve metabolic process
GO:0016301 IEA kinase activity
GO:0016311 IEA dephosphorylation
GO:0019900 IEA kinase binding
GO:0031100 IEA organ regeneration
GO:0032868 IEA response to insulin
GO:0033133 IEA positive regulation of glucokinase activity
GO:0033762 IEA response to glucagon
GO:0035556 TAS intracellular signal transduction
GO:0042594 IEA response to starvation
GO:0042802 IEA identical protein binding
GO:0043540 IDA 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
GO:0044281 TAS small molecule metabolic process
GO:0046835 IEA carbohydrate phosphorylation
GO:0051384 IEA response to glucocorticoid
GO:0051591 IEA response to cAMP
GO:0070095 IEA fructose-6-phosphate binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037140 pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 protein_coding Danio_rerio
ENSDARG00000074457 PFKFB1 (2 of 2) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 protein_coding Danio_rerio
ENSMUSG00000025271 Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 protein_coding Mus_musculus

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