C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: autocrine motility factor receptor, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000159461 AMFR 9606 - 16:56361452-56425538 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000290649 AMFR-001 56361452-56425538 protein_coding
  ENST00000492830 AMFR-002 56361560-56403117 protein_coding
  ENST00000563285 AMFR-012 56362916-56367603 retained_intron
  ENST00000563664 AMFR-007 56404968-56424871 protein_coding
  ENST00000564283 AMFR-008 56414321-56424195 processed_transcript
  ENST00000565445 AMFR-005 56402986-56424995 protein_coding
  ENST00000566334 AMFR-011 56367291-56385972 retained_intron
  ENST00000566757 AMFR-004 56362002-56363845 retained_intron
  ENST00000567738 AMFR-009 56364080-56403103 protein_coding
  ENST00000568325 AMFR-003 56362023-56364116 retained_intron
  ENST00000568657 AMFR-006 56408008-56424978 processed_transcript
  ENST00000568762 AMFR-010 56385642-56401775 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000290649ENST00000492830ENST00000563664ENST00000567738ENST00000568325
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000290649 6.544±0.00 4.328±0.00 3.024±0.00 8.286±3.78 7.997±6.17 7.754±1.55 7.551±4.76 20.421±9.63 19.449±0.00 7.249±5.40 46.055±41.41 7.461±4.54 7.510±1.13 N/A
ENST00000492830 7.615±0.00 N/A N/A 13.613±0.00 10.857±0.00 8.451±0.00 N/A 11.857±5.46 20.280±0.00 7.462±0.00 53.170±0.00 7.995±0.00 5.595±0.00 16.165±0.00
ENST00000563664 N/A N/A 19.663±0.00 21.036±0.00 12.316±0.00 N/A 11.251±0.00 N/A 19.576±0.00 N/A 39.215±0.00 N/A N/A N/A
ENST00000567738 N/A 17.517±0.00 N/A N/A N/A N/A 11.343±0.00 46.955±0.00 N/A 14.208±0.00 12.998±0.00 17.244±0.00 43.492±0.00 92.098±0.00
ENST00000568325 24.945±0.00 32.378±0.00 14.035±0.00 16.724±1.35 18.886±9.86 15.058±2.26 8.920±3.67 44.226±24.69 21.523±9.48 21.194±0.00 77.913±56.23 22.698±7.63 32.009±21.75 76.108±35.57

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00048U CIL_00048U_0001 CGP 16:56191390-56425538
CIL_00048T CIL_00048T_0001 CGP 16:56361452-56452199

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000209 IDA protein polyubiquitination
GO:0000836 IDA Hrd1p ubiquitin ligase complex
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0004872 IPI receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005789 IDA endoplasmic reticulum membrane
GO:0006511 IMP ubiquitin-dependent protein catabolic process
GO:0006928 TAS cellular component movement
GO:0007165 TAS signal transduction
GO:0007568 IEA aging
GO:0007611 IEA learning or memory
GO:0008270 IEA zinc ion binding
GO:0016020 IDA membrane
GO:0016021 NAS integral component of membrane
GO:0016874 IEA ligase activity
GO:0030176 IDA integral component of endoplasmic reticulum membrane
GO:0030425 IEA dendrite
GO:0030426 IEA growth cone
GO:0030433 IDA ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 IMP endoplasmic reticulum unfolded protein response
GO:0043025 IEA neuronal cell body
GO:0043234 IDA protein complex
GO:0046872 IEA metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0051259 IDA protein oligomerization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000020218 amfr autocrine motility factor receptor protein_coding Danio_rerio
ENSDARG00000053049 AMFR (2 of 2) autocrine motility factor receptor, E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSMUSG00000031751 Amfr autocrine motility factor receptor protein_coding Mus_musculus

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