C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ADAM metallopeptidase with thrombospondin type 1 motif, 13
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160323 ADAMTS13 9606 + 9:133414358-133459402 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000355699 ADAMTS13-002 133422324-133459386 protein_coding
  ENST00000356589 ADAMTS13-003 133422324-133459386 protein_coding
  ENST00000371910 ADAMTS13-006 133455648-133459386 protein_coding
  ENST00000371911 ADAMTS13-201 133422324-133429910 protein_coding
  ENST00000371916 ADAMTS13-202 133422000-133459402 protein_coding
  ENST00000371929 ADAMTS13-001 133422000-133459386 protein_coding
  ENST00000474918 ADAMTS13-008 133422325-133448609 nonsense_mediated_decay
  ENST00000485925 ADAMTS13-004 133414358-133459386 processed_transcript
  ENST00000495234 ADAMTS13-007 133422324-133449956 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000355699ENST00000356589ENST00000371910ENST00000371911ENST00000371916ENST00000371929ENST00000474918ENST00000485925ENST00000495234
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000355699 N/A N/A 0.169±0.00 N/A N/A N/A N/A 0.398±0.00 N/A 0.092±0.00 N/A 0.457±0.00 N/A N/A
ENST00000356589 N/A 0.173±0.00 N/A N/A N/A N/A N/A N/A 1.702±0.00 N/A 0.042±0.00 N/A N/A N/A
ENST00000371910 N/A 0.255±0.00 0.487±0.00 0.732±0.19 0.612±0.00 0.343±0.00 0.416±0.00 N/A 2.096±0.00 0.541±0.00 0.231±0.12 0.110±0.00 0.171±0.00 1.009±0.00
ENST00000371911 N/A N/A 0.180±0.00 N/A 0.075±0.00 N/A N/A N/A N/A N/A 0.247±0.00 N/A N/A N/A
ENST00000371916 0.119±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000371929 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.125±0.00 N/A 0.515±0.00 0.101±0.00 0.315±0.00
ENST00000474918 N/A N/A N/A N/A N/A N/A N/A N/A 0.226±0.00 0.196±0.00 N/A N/A 0.182±0.00 N/A
ENST00000485925 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.092±0.00 N/A
ENST00000495234 0.036±0.00 N/A N/A N/A N/A N/A N/A 0.991±0.00 N/A 0.121±0.00 N/A 0.083±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000KH CIL_0000KH_0001 CGP 9:133376367-133418096
CIL_0006DF CIL_0006DF_0001 CGP 9:133406059-133459402
CIL_0006DA CIL_0006DA_0001 CGP 9:133414358-133470848

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004175 IEA endopeptidase activity
GO:0004222 IEA metalloendopeptidase activity
GO:0005178 TAS integrin binding
GO:0005509 TAS calcium ion binding
GO:0005515 IPI protein binding
GO:0005578 TAS proteinaceous extracellular matrix
GO:0005615 IEA extracellular space
GO:0006508 IDA:IEA proteolysis
GO:0007160 NAS cell-matrix adhesion
GO:0007229 NAS integrin-mediated signaling pathway
GO:0008233 IEA peptidase activity
GO:0008237 TAS metallopeptidase activity
GO:0008270 TAS zinc ion binding
GO:0009100 NAS glycoprotein metabolic process
GO:0009636 IEA response to toxic substance
GO:0009986 NAS cell surface
GO:0016485 TAS protein processing
GO:0030168 NAS platelet activation
GO:0031012 IEA extracellular matrix
GO:0034341 IEA response to interferon-gamma
GO:0034612 IEA response to tumor necrosis factor
GO:0043171 IDA peptide catabolic process
GO:0070670 IEA response to interleukin-4

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076270 adamts13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 protein_coding Danio_rerio
ENSMUSG00000014852 Adamts13 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 protein_coding Mus_musculus

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