C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor receptor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000160867 FGFR4 9606 + 5:177086886-177098144 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000292408 FGFR4-001 177086886-177098144 protein_coding
  ENST00000393637 FGFR4-002 177089567-177097769 protein_coding
  ENST00000393648 FGFR4-003 177086905-177098022 protein_coding
  ENST00000426612 FGFR4-006 177089598-177091096 retained_intron
  ENST00000430285 FGFR4-005 177089576-177091104 nonsense_mediated_decay
  ENST00000483872 FGFR4-015 177094825-177095579 retained_intron
  ENST00000502906 FGFR4-004 177086914-177097732 protein_coding
  ENST00000503708 FGFR4-010 177086905-177091104 protein_coding
  ENST00000507708 FGFR4-011 177086916-177090563 processed_transcript
  ENST00000508139 FGFR4-013 177091778-177093496 retained_intron
  ENST00000509511 FGFR4-007 177089603-177093068 retained_intron
  ENST00000510911 FGFR4-009 177086916-177090560 protein_coding
  ENST00000511076 FGFR4-014 177093175-177096179 protein_coding
  ENST00000513166 FGFR4-008 177087419-177090622 protein_coding
  ENST00000513423 FGFR4-016 177097191-177097764 retained_intron
  ENST00000514472 FGFR4-012 177086914-177090641 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000292408ENST00000393637ENST00000393648ENST00000426612ENST00000430285ENST00000483872ENST00000502906ENST00000503708ENST00000508139ENST00000510911ENST00000511076ENST00000513423ENST00000514472
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000292408 0.044±0.00 N/A N/A N/A N/A 0.772±0.00 N/A 15.067±0.00 14.656±0.00 34.809±0.00 N/A 10.051±5.22 0.857±0.47 0.763±0.00
ENST00000393637 N/A N/A N/A N/A 0.058±0.00 N/A 0.018±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000393648 N/A N/A N/A 0.055±0.00 0.305±0.00 N/A 0.090±0.00 3.778±0.00 3.053±0.00 N/A 0.123±0.00 4.617±0.00 0.603±0.16 1.086±0.00
ENST00000426612 N/A N/A 1.652±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000430285 N/A N/A 1.168±0.00 N/A N/A N/A N/A N/A 0.233±0.00 N/A N/A N/A N/A N/A
ENST00000483872 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.041±0.00 N/A N/A N/A N/A
ENST00000502906 N/A 0.406±0.00 N/A N/A N/A N/A N/A 1.979±0.00 N/A 0.366±0.00 N/A 7.213±0.00 0.887±0.09 N/A
ENST00000503708 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.121±0.00 N/A 0.825±0.00 N/A N/A
ENST00000508139 N/A N/A N/A N/A N/A N/A 0.155±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000510911 0.109±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.412±0.00
ENST00000511076 0.152±0.00 N/A N/A 0.239±0.00 0.455±0.00 N/A N/A N/A 0.126±0.00 N/A N/A N/A N/A N/A
ENST00000513423 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.661±0.00 N/A N/A N/A
ENST00000514472 N/A N/A N/A 0.087±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 1.058±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000OR CIL_0000OR_0002 CGP 5:177022696-177098144
CIL_0000OQ CIL_0000OQ_0002 CGP 5:177086886-177300215

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001759 IEA organ induction
GO:0004672 IEA protein kinase activity
GO:0004713 TAS:IEA protein tyrosine kinase activity
GO:0005007 IGI:IEA fibroblast growth factor-activated receptor activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005783 IDA endoplasmic reticulum
GO:0005886 TAS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IEA protein phosphorylation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008201 IDA heparin binding
GO:0008284 IDA:IEA positive regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 IPI:IEA fibroblast growth factor receptor signaling pathway
GO:0010715 IMP regulation of extracellular matrix disassembly
GO:0016021 IEA integral component of membrane
GO:0016477 IMP cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017134 IPI fibroblast growth factor binding
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019216 ISS regulation of lipid metabolic process
GO:0030324 IEA lung development
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042593 ISS glucose homeostasis
GO:0045087 TAS innate immune response
GO:0045862 IMP positive regulation of proteolysis
GO:0046777 IDA protein autophosphorylation
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048554 IMP positive regulation of metalloenzyme activity
GO:0055062 ISS phosphate ion homeostasis
GO:0061144 IEA alveolar secondary septum development
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0070857 IMP regulation of bile acid biosynthetic process
GO:2000188 ISS regulation of cholesterol homeostasis
GO:2000573 IMP positive regulation of DNA biosynthetic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069105 fgfr4 fibroblast growth factor receptor 4 protein_coding Danio_rerio
ENSMUSG00000005320 Fgfr4 fibroblast growth factor receptor 4 protein_coding Mus_musculus

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