C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurofascin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163531 NFASC 9606 + 1:204828651-205022822 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000339876 NFASC-201 204828654-205022821 protein_coding
  ENST00000360049 NFASC-202 204828654-205022821 protein_coding
  ENST00000367173 NFASC-006 204950557-205018371 protein_coding
  ENST00000401399 NFASC-001 204920632-205022822 protein_coding
  ENST00000403080 NFASC-003 204828695-204977139 protein_coding
  ENST00000404076 NFASC-012 204870831-205018371 protein_coding
  ENST00000404907 NFASC-010 204944226-205018371 protein_coding
  ENST00000404977 NFASC-002 204828651-205010924 processed_transcript
  ENST00000413225 NFASC-017 204988664-205016386 protein_coding
  ENST00000425360 NFASC-004 204981856-205018371 protein_coding
  ENST00000430393 NFASC-011 204944388-205018371 protein_coding
  ENST00000447819 NFASC-007 204997184-205018739 protein_coding
  ENST00000468328 NFASC-015 204981884-204988806 processed_transcript
  ENST00000471392 NFASC-016 204979388-204984329 processed_transcript
  ENST00000492085 NFASC-008 204987470-205000846 processed_transcript
  ENST00000493914 NFASC-014 204870604-204945032 processed_transcript
  ENST00000495396 NFASC-005 204986675-205022822 processed_transcript
  ENST00000503221 NFASC-023 205008445-205021031 retained_intron
  ENST00000504149 NFASC-025 204957658-204968825 processed_transcript
  ENST00000504476 NFASC-021 204944251-205016938 nonsense_mediated_decay
  ENST00000505079 NFASC-024 204929409-204954361 protein_coding
  ENST00000512826 NFASC-022 204957695-204990563 retained_intron
  ENST00000513543 NFASC-018 204944251-205016938 protein_coding
  ENST00000514644 NFASC-020 204870862-204974683 retained_intron
  ENST00000539706 NFASC-203 204828654-205022821 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000339876ENST00000360049ENST00000367173ENST00000401399ENST00000447819ENST00000492085ENST00000495396ENST00000503221ENST00000512826ENST00000539706
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000339876 N/A N/A N/A 4.069±0.00 N/A 0.507±0.00 0.887±0.00 N/A N/A N/A N/A 2.198±0.00 N/A N/A
ENST00000360049 N/A N/A N/A N/A N/A N/A N/A 1.211±0.00 N/A N/A N/A N/A N/A N/A
ENST00000367173 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.385±0.00 N/A 0.425±0.00 N/A N/A
ENST00000401399 0.583±0.00 1.628±0.00 N/A 7.535±0.00 0.528±0.01 1.879±0.00 N/A N/A N/A 1.876±0.00 0.723±0.00 1.173±0.96 N/A 1.919±0.00
ENST00000447819 N/A N/A N/A N/A N/A N/A N/A N/A 0.880±0.00 N/A N/A N/A N/A N/A
ENST00000492085 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.599±0.00 N/A N/A N/A N/A
ENST00000495396 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.506±0.60 4.485±0.00 N/A
ENST00000503221 N/A N/A 5.380±0.00 N/A N/A 1.239±0.00 0.551±0.00 0.547±0.00 N/A 0.479±0.00 0.329±0.00 1.289±0.00 N/A N/A
ENST00000512826 N/A N/A N/A N/A 1.389±0.00 1.111±0.00 0.588±0.00 N/A N/A N/A N/A 0.824±0.00 N/A N/A
ENST00000539706 N/A N/A N/A 9.792±8.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.413±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00057C CIL_00057C_0002 CGP 1:204828651-205078499

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002175 IEA protein localization to paranode region of axon
GO:0005515 IPI:IEA protein binding
GO:0005622 ISS intracellular
GO:0005886 TAS plasma membrane
GO:0005925 IDA focal adhesion
GO:0007411 TAS axon guidance
GO:0007422 IEA:ISS peripheral nervous system development
GO:0016021 IEA integral component of membrane
GO:0019226 IEA transmission of nerve impulse
GO:0030424 IEA axon
GO:0030913 IEA paranodal junction assembly
GO:0033010 IEA paranodal junction
GO:0033268 ISS node of Ranvier
GO:0033270 IEA paranode region of axon
GO:0034113 IEA heterotypic cell-cell adhesion
GO:0042552 ISS myelination
GO:0043194 ISS axon initial segment
GO:0045162 IEA clustering of voltage-gated sodium channels
GO:0050808 IEA synapse organization
GO:0070062 IDA extracellular vesicular exosome
GO:0071205 IEA protein localization to juxtaparanode region of axon
GO:0086080 IEA protein binding involved in heterotypic cell-cell adhesion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000056910 NFASC (1 of 2) neurofascin protein_coding Danio_rerio
ENSDARG00000061099 nfasca neurofascin homolog (chicken) a protein_coding Danio_rerio
ENSMUSG00000026442 Nfasc neurofascin protein_coding Mus_musculus

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