C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163738 MTHFD2L 9606 + 4:74114174-74303099 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000325278 MTHFD2L-001 74158173-74303099 protein_coding
  ENST00000359107 MTHFD2L-011 74158150-74281550 protein_coding
  ENST00000395759 MTHFD2L-201 74158112-74303092 protein_coding
  ENST00000423607 MTHFD2L-009 74158108-74183931 nonsense_mediated_decay
  ENST00000429335 MTHFD2L-008 74123344-74181750 nonsense_mediated_decay
  ENST00000429519 MTHFD2L-005 74114174-74242210 nonsense_mediated_decay
  ENST00000433372 MTHFD2L-202 74125438-74242197 protein_coding
  ENST00000461101 MTHFD2L-010 74158118-74162253 processed_transcript
  ENST00000461856 MTHFD2L-003 74224068-74301990 processed_transcript
  ENST00000465255 MTHFD2L-004 74280241-74302635 processed_transcript
  ENST00000475291 MTHFD2L-007 74123339-74160770 retained_intron
  ENST00000484725 MTHFD2L-012 74158175-74162106 processed_transcript
  ENST00000490128 MTHFD2L-013 74281425-74293675 processed_transcript
  ENST00000490698 MTHFD2L-006 74123273-74160514 retained_intron
  ENST00000492183 MTHFD2L-002 74194040-74302598 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000325278ENST00000359107ENST00000395759ENST00000423607ENST00000429335ENST00000433372ENST00000461101ENST00000475291ENST00000490698
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000325278 N/A N/A N/A N/A N/A N/A 1.360±0.00 N/A N/A N/A N/A 0.618±0.15 0.308±0.00 N/A
ENST00000359107 N/A N/A 0.701±0.00 5.023±0.00 1.484±0.00 1.255±0.00 2.893±0.00 N/A 2.865±0.00 1.723±0.00 N/A 2.310±1.40 0.731±0.00 N/A
ENST00000395759 0.323±0.00 N/A N/A 1.360±0.00 0.921±0.00 0.587±0.00 N/A N/A 0.862±0.00 N/A 0.519±0.00 N/A N/A 0.557±0.00
ENST00000423607 N/A N/A N/A N/A N/A 0.526±0.00 N/A 0.659±0.00 N/A 0.426±0.00 N/A N/A 0.177±0.00 1.151±0.00
ENST00000429335 N/A N/A N/A N/A N/A N/A N/A 2.667±0.00 N/A N/A 0.693±0.00 N/A N/A N/A
ENST00000433372 N/A 1.412±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.662±0.00 N/A N/A
ENST00000461101 0.411±0.00 1.662±0.00 0.514±0.00 1.373±0.25 1.162±0.00 1.126±0.26 1.202±0.13 2.760±0.95 N/A 0.505±0.00 0.334±0.00 1.178±0.52 0.446±0.18 N/A
ENST00000475291 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.697±0.54 0.495±0.00 N/A 0.463±0.00 1.414±0.00
ENST00000490698 0.692±0.00 N/A N/A N/A N/A 1.177±0.00 N/A N/A 3.576±0.00 N/A N/A N/A 1.210±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00035M CIL_00035M_0001 CGP 4:74097035-74303099
CIL_0006SN CIL_0006SN_0001 CGP 4:74114174-74315307

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000105 IEA histidine biosynthetic process
GO:0003824 IEA catalytic activity
GO:0004477 IBA methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 IBA methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 IEA:IBA methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005739 IBA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0006164 IEA purine nucleotide biosynthetic process
GO:0006730 IBA one-carbon metabolic process
GO:0009086 IEA methionine biosynthetic process
GO:0009396 IEA folic acid-containing compound biosynthetic process
GO:0035999 IEA tetrahydrofolate interconversion
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054199 mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like protein_coding Danio_rerio
ENSMUSG00000029376 Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like protein_coding Mus_musculus

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