C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000163947 ARHGEF3 9606 - 3:56727418-57079329 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000296315 ARHGEF3-001 56727418-56801967 protein_coding
  ENST00000338458 ARHGEF3-002 56727418-57079308 protein_coding
  ENST00000413728 ARHGEF3-003 56727421-56775657 protein_coding
  ENST00000465659 ARHGEF3-004 56728232-56801949 nonsense_mediated_decay
  ENST00000468466 ARHGEF3-011 56773709-57079265 protein_coding
  ENST00000468727 ARHGEF3-008 56751118-57079308 protein_coding
  ENST00000473779 ARHGEF3-010 56751300-56977375 protein_coding
  ENST00000477440 ARHGEF3-015 56755072-57078815 processed_transcript
  ENST00000477833 ARHGEF3-012 56754981-57079329 nonsense_mediated_decay
  ENST00000481422 ARHGEF3-013 56751349-56939909 processed_transcript
  ENST00000486829 ARHGEF3-009 56773767-56977375 nonsense_mediated_decay
  ENST00000495373 ARHGEF3-006 56731593-56801949 protein_coding
  ENST00000496106 ARHGEF3-007 56728987-56916471 protein_coding
  ENST00000497267 ARHGEF3-005 56729021-56775567 protein_coding
  ENST00000498517 ARHGEF3-014 56753494-56939907 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000296315ENST00000338458ENST00000413728ENST00000465659ENST00000495373ENST00000496106ENST00000497267
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000296315 5.725±0.00 4.720±0.00 N/A 5.157±2.05 2.412±2.06 5.752±0.00 2.277±0.00 8.977±8.80 0.496±0.00 6.824±4.20 2.124±0.00 7.166±2.90 7.706±0.48 9.468±0.00
ENST00000338458 N/A 1.596±0.00 N/A N/A 0.509±0.00 1.106±0.34 0.535±0.00 N/A N/A N/A N/A 2.076±2.02 1.710±0.00 1.425±0.00
ENST00000413728 N/A N/A N/A 1.810±0.00 N/A 0.641±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000465659 N/A N/A 1.510±0.00 N/A N/A 0.733±0.00 N/A 0.412±0.00 1.862±0.00 N/A N/A 1.901±0.98 7.270±0.00 7.323±0.00
ENST00000495373 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.507±0.00 N/A N/A N/A
ENST00000496106 N/A N/A N/A N/A N/A 1.029±0.00 0.461±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000497267 N/A N/A N/A 1.741±0.00 N/A N/A N/A N/A 1.733±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007UE CIL_0007UE_0001 VISTA 3:56468385-57070064

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005622 IDA intracellular
GO:0005829 TAS cytosol
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007266 TAS Rho protein signal transduction
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013834 arhgef3 Rho guanine nucleotide exchange factor (GEF) 3 protein_coding Danio_rerio
ENSMUSG00000021895 Arhgef3 Rho guanine nucleotide exchange factor (GEF) 3 protein_coding Mus_musculus

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